Allele frequency calculation

Allele frequency calculation

0

Hello everyone,
I use vcf tools to find AF values by using this command:

vcftools --gzvcf $SUBSET_VCF --freq2 --out $OUT --max-alleles 2

The output I got from this is:

chr      pos nalleles  nchr    a1     a2    
  <dbl>    <dbl>    <dbl> <dbl> <dbl>  <dbl>  
1    22 16050408        2   846 0.944 0.0556 
2    22 16050612        2   846 0.937 0.0626 
3    22 16050678        2   846 0.948 0.0520 
4    22 16050984        2   846 1     0      
5    22 16051107        2   846 0.943 0.0567 
6    22 16051249        2   846 0.927 0.0733 

Now I know in order to find minor allele frequency (MAF): i use this command:
find minor allele frequency

var_freq$maf <- var_freq %>% select(a1, a2) %>% apply(1, function(z) min(z))

But I need to plot total allele frequency and not MAF. Should i consider both a1 and a2 value for plotting?


AF


VCF


snp


calc

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