Identification of transcription factors from a list of DEGs

Hello everyone,
I have a list of 245 DEGs . I separated it into unregulated and downregulated based on Fc value .
I want to know whether I need to seperately analyze DEGs as( upregulated or downregulated )for identifying TFs .
TFs for unregulated genes
TFs for downregulated genes
Or can I use the whole DEGs as together to identify TFs ?
Which one is correct ?
Please help me ..