Clustering without having any replication

I have raw read counts of three different samples (sub-types) with no replications

like this

> head(oc)
          sample1 sample2 sample3
WASH7P          3      29      48
MIR6859-1       0       6       4
DDX11L17        0       2       2
WASH9P          3      92     101
MTND1P23        8     154     139
MTND2P28     3104    3491    3814
> 

How I can normalise this data frame because both of edger and deseq2 software needs a design of conditions

My ultimate goal is having clustering of genes in these samples but for that I would need normalised counts

Thanks for any help