PhD position (Ageing & Disease, Bioinformatics & Computational Biology): Reprogramming of immune and vascular cells in disease (m/f/d), Mainz – Institute of Molecular Biology gGmbH – Biology & Life Sciences

The hematopoietic system is maintained by a constant replenishment of blood cells from stem and progenitor populations in the bone marrow. Megakaryocytes are a key cell type in the bone marrow that generate blood platelets as well as maintain hematopoietic stem cells and the output of lineage committed progenitors. Platelet transcriptomics is an approach to gain insight into the differentiation and function of megakaryocytes in inflammatory diseases and aging. The cross species comparison of transcriptomes from genetically modified mice subjected to diseases models with human samples can yield new mechanistic insights in diseases processes that involve the hematopoietic system and its regulation by coagulation proteases and their cognate G protein-coupled receptors.

PhD Project: Platelet transcriptomics: from mice to man

This is a project focused on bioinformatics with the goal to analyze available large data sets and perform comparison with data sets available publically.

All you need is:

• Master or equivalent
• Interactive personality & good command of English
• 2 letters of reference

• Exciting, interdisciplinary projects in a fully international environment, with English as our working language
• Advanced training in scientific techniques and professional skills
• Access to our state-of-the-art Core Facilities and their technical expertise
• Fully funded positions with financing until the completion of your thesis
• A lively community of more than 150 PhD students from 40 different countries