PRS from a dataset on which the GWAS is based on
I am using the PRSice tool to calculate PRS scores for a dataset (d1) using a set of weights from the PGS catalog. Although the weights were generated from a different cohort (d2), it appears that the original GWAS was based on the same dataset (d1) that I’m using. Does this method inflate the predictive qualities of the PRS for the cohort in d1? Or should we even use it in that case? (Still very new to the concept of PRS scores)
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