KEGG ENZYME: 3.6.1.22

Entry
EC 3.6.1.22                 Enzyme                                 
Name

NAD+ diphosphatase;
NPY1 (gene name);
nudC (gene name);
NUDT7 (gene name);
nicotinamide adenine dinucleotide pyrophosphatase;
NADP pyrophosphatase;
NADH pyrophosphatase;
NAD+ phosphohydrolase

Class

Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides

Sysname

NAD(H) phosphohydrolase

Reaction(IUBMB) Reaction(KEGG) Substrate Product Comment

This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences. Also acts on other dinucleotides, including NADP(H), FAD(H2), and the thionicotinamide analogues of NAD+ and NADP+.

History

EC 3.6.1.22 created 1972

Pathway
ec00760   Nicotinate and nicotinamide metabolism
Orthology Genes  » show all
Reference

1

  Authors

Kornberg, A. and Pricer, W.E.

  Title

Nucleotide pyrophosphatase.

  Journal

J Biol Chem 182:763-778 (1950)

Reference   Authors

JACOBSON KB, KAPLAN NO.

  Title

A reduced pyridine nucleotide pyrophosphatase.

  Journal

J Biol Chem 226:427-37 (1957)

Reference   Authors

SWARTZ MN, KAPLAN NO, LAMBORG MF.

  Title

A heat-activated diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris.

  Journal

J Biol Chem 232:1051-63 (1958)

Reference   Authors

Kumar SA, Rao NA, Vaidyanathan CS.

  Title

Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings (Phaseolus radiatus).

  Journal Reference   Authors

Anderson BM, Lang CA.

  Title

Nicotinamide-adenine dinucleotide pyrophosphatase in the growing and aging mosquito.

  Journal Reference   Authors

Nakajima Y, Fukunaga N, Sasaki S, Usami S.

  Title

Purification and properties of NADP pyrophosphatase from Proteus vulgaris.

  Journal Reference   Authors

Frick DN, Bessman MJ

  Title

Cloning, purification, and properties of a novel NADH pyrophosphatase. Evidence for a nucleotide pyrophosphatase catalytic domain in MutT-like enzymes.

  Journal   Sequence Reference   Authors

Xu W, Dunn CA, Bessman MJ

  Title

Cloning and characterization of the NADH pyrophosphatases from Caenorhabditis elegans and Saccharomyces cerevisiae, members of a Nudix hydrolase subfamily.

  Journal   Sequence Reference   Authors

Jambunathan N, Mahalingam R

  Title

Analysis of Arabidopsis growth factor gene 1 (GFG1) encoding a nudix hydrolase during oxidative signaling.

  Journal   Sequence Other DBs
ExplorEnz – The Enzyme Database:  3.6.1.22
ExPASy – ENZYME nomenclature database:  3.6.1.22

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