Tag: iPSCs

Visiongain Reports Ltd Visiongain has published a new report entitled: Translational Regenerative Medicine Market Report 2024-2034: Forecasts by Product (Stem Cell Therapy (Autologous, Allogenic), Tissue Engineering (Scaffold, Hydrogels), Gene Therapy, Others)), by Application (Oncology, Dermatology, Musculoskeletal, Neurology, Cardiovascular, Wound Healing, Ophthalmology, Others) AND Regional and Leading National Market Analysis PLUS…

Visiongain has published a new report entitled: Translational Regenerative Medicine Market Report 2024-2034: Forecasts by Product (Stem Cell Therapy (Autologous, Allogenic), Tissue Engineering (Scaffold, Hydrogels), Gene Therapy, Others)), by Application (Oncology, Dermatology, Musculoskeletal, Neurology, Cardiovascular, Wound Healing, Ophthalmology, Others) AND Regional and Leading National Market Analysis PLUS Analysis of Leading…

The UK is home to several biotech hubs, including the famous ‘golden triangle’, made up of Oxford, Cambridge, and London. In fact, after a $700 million surge in funding in the third quarter of 2023, the UK biotech scene is now one of the most vibrant in Europe, laying the…

About iPSCs (induced pluripotent stem cells), an inexhaustible source of functional human cells, have enormous potential for biomedical research and health care. They are being used to study genetic disease, new drug development, and treatment of a broad range of disorders — diabetes, cancer, neurological illnesses, and more. This forum…

Researchers observed many quantifiable differences between diseased cells made from affected children and their gene-edited cells. Researchers from the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center and collaborators at Washington University School of Medicine have shown how they can now study the most common genetic…

Unleashing the Potential of Induced Pluripotent Stem Cells (iPSCs) Induced pluripotent stem cells (iPSCs) represent a groundbreaking scientific discovery with vast potential for biomedical research and healthcare. These cells, which can be generated from a patient’s own tissues, can differentiate into any cell type in the body, thus providing an…

Natural killer (NK) cells are white blood cells that are a part of the body’s defense mechanism. These cells are on the lookout for any kind of disruption in the immune system, and can kill diseased cells like tumor cells. NK cells are being used in clinical applications to treat…

A Look at Cell and Gene Therapies in Japan and Beyond Over the past few years, there has been a growing focus on cell and gene therapies worldwide, with Japan leading the way in their approval. The complex process of such therapies’ approval involves several stages, including randomized clinical trials…

Market Overview The Middle East and Africa (MEA) region is witnessing significant advancements in the field of regenerative medicine, particularly in the area of induced pluripotent stem cells (iPSCs). iPSCs are derived from adult cells and possess the remarkable ability to differentiate into various cell types, making them a valuable…

PRESS RELEASE Published December 18, 2023 Creative Biolabs, a leading biotechnology company, is proud to announce the launch of its cutting-edge neuronal differentiation technologies, designed to propel scientific research in the fields of neurobiology, regenerative medicine, and drug discovery. New York, USA – December 18, 2023 – Advances in neuroscience…

Natural killer (NK) cells are innate lymphocytes that play a key role in the control of infection and malignancy. NK cells are potent killers of target cells and act in an MHC-independent manner, enabling their application as allogenic therapy for cancer. Human iPSCs are pluripotent with the ability to self-renew,…

. 2023 Nov 30:11:1302448. doi: 10.3389/fcell.2023.1302448. eCollection 2023. Affiliations Expand Affiliations 1 Institute for Stem Cell Biology, RWTH Aachen University Medical School, Aachen, Germany. 2 Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany. Item in Clipboard Deepika Puri et al. Front Cell Dev Biol. 2023. Show details Display…

Fate Therapeutics, Inc. SAN DIEGO, Dec. 13, 2023 (GLOBE NEWSWIRE) — Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to bringing a first-in-class pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients with cancer and autoimmune disorders, today announced that the Company granted a non-qualified stock…

Shinobi Therapeutics – a biotechnology company developing a new class of immune evasive iPS-T cell therapies – recently announced that it has closed a $51 million Series A financing. The oversubscribed funding round was led by EQT Life Sciences, F-Prime Capital, and Eight Roads Ventures Japan, with participation from Astellas…

Cellular immunotherapy—for example, Chimeric Antigen Receptor (CAR)-T cell therapy—has shown great efficacy in treating various hematologic malignancies. CAR-T therapy has undergone notable changes, and several drugs have received regulatory approval for commercial use. Despite these achievements, substantial challenges remain in the widespread use of autologous CAR-T therapy, such as the…

12/13/2023 PITTSBURGH — University of Pittsburgh researchers have developed a new embryo-like model derived from adult cells that replicates key features of early human development, including the generation of blood cells. Described today in Nature, the new heX-Embryoid model provides a unique window into early human development, which has been shrouded in mystery because of…

%PDF-1.7 % 1 0 obj <>/Metadata 5 0 R/Outlines 2 0 R/Pages 3 0 R/StructTreeRoot 4 0 R/Type/Catalog/ViewerPreferences 6 0 R>> endobj 5 0 obj <>stream application/pdf Karina de Oliveira Brandão Gain of chromosome region 1q31.3 in human iPSCs confers growth advantage and alters contraction in derivative cardiomyocytes Microsoft Word 2023-12-11T15:41:33Z…

Adress the main ideas of the passage below. Stem cell research has emerged as a groundbreaking field with the potential to revolutionize regenerative medicine. This scientific pursuit harnesses the remarkable properties of pluripotent and multipotent stem cells, such as embryonic stem cells and induced pluripotent stem cells (iPSCs). These cells…

Proceeds to support company in advancing its first off-the-shelf iPS-T cell therapy against GPC3+ cancers toward the clinic Oversubscribed Series A led by EQT Life Sciences, F-Prime Capital and Eight Roads Ventures Japan, with participation from Astellas Venture Management, Fast Track Initiative (FTI), JIC Venture Growth Investments, and D3 LLC…

By Vivienne Raper, PhD A company founded on deep knowledge of semiconductors is working on a technology designed to efficiently characterize cells for advanced therapy medicinal products (ATMPs). Cytomos, which presented at a Dragon’s Den session at bioProcessUK last month, is using electrical fields to measure cell properties. The insights…

Did Michael J Fox try stem cells? In recent years, there has been much speculation surrounding the renowned actor Michael J Fox and his potential use of stem cells to treat his Parkinson’s disease. Stem cell therapy has gained attention as a promising avenue for various medical conditions, including Parkinson’s,…

Induced pluripotent stem cells (iPSCs) have the ability to differentiate into a variety of tissues and cell types. They are a promising cell source for cell therapy for damaged skeletal muscle and inherited muscle diseases such as Duchenne muscular dystrophy (DMD). However, current transplantation studies have revealed that the…

The history of using genes as a tool to treat humans goes back nearly five decades, marking a pivotal moment in medical science.  In 1972, the concept of gene therapy was first considered as a form of treatment. This groundbreaking idea was introduced in a paper titled “Gene therapy for…

Market Overview and Report Coverage An iPSC generation kit is a kit used to generate induced pluripotent stem cells (iPSCs) from somatic cells. iPSCs are adult cells that have been reprogrammed to revert to an embryonic-like state, which enables them to differentiate into any type of cell in the human…

Market Overview and Report Coverage The iPSC Differentiation Kit is a tool used in stem cell research to guide the differentiation of induced pluripotent stem cells (iPSCs) into specific cell types or lineages. iPSCs are created by reprogramming adult cells to revert to a stem cell-like state, allowing them to…

PRESS RELEASE Published December 6, 2023 Global iPSCs Manufacturing Services Market  worth $2.61 Billion by 2030 – Exclusive Report by InsightAce Analytic InsightAce Analytic Pvt. Ltd. has announced the publication of a market research report titled “Global iPSCs Manufacturing Services Market  (By Application (Research Products, Drug Development & Discovery, Cellular…

A novel framework developed by researchers at Northeastern University in Boston could revolutionize the production of therapies from induced pluripotent stem cells (iPSCs). The framework, called biological system-of-systems (Bio-SoS), incorporates a multi-scale bioprocess mechanistic model to simplify the scaling up of iPSC production. Traditionally, producing therapies from iPSCs involves numerous…

Mitochondria dysfunction is linked to hypertrophic cardiomyopathy — when the heart becomes enlarged and cannot pump blood efficiently — in people with Pompe disease, according to a new study from China. The disease-causing mechanisms were explored in a patient-derived heart cell model with characteristics of Pompe disease, including low levels…

360 Research Reports has published a new report titled as “Induced Pluripotent Stem Cells (iPSCs) Market” by End User (Academic Research, Drug Development and Discovery, Toxicity Screening, Regenerative Medicine, Others), Types (TYPE1), Region and Global Forecast to 2023-2030. This Exclusive Data Report also presents qualitative and quantitative perspectives on SWOT…

DMD is a degenerative, fatal, and incurable muscular dystrophy that is typically diagnosed between the ages of three and four. Affected boys have increasing muscle weakness and cardiorespiratory and orthopedic complications and are at risk of cognitive, behavioral, and language difficulties30. Suspected cases often undergo DMD gene mutation screening to…

Market Overview and Report Coverage Induced Pluripotent Stem Cells (iPSCs) are a type of stem cell that can be created by reprogramming adult cells, such as skin cells, back into an embryonic-like state. These cells have the ability to differentiate into nearly any cell type in the human body, making…

Nicola Bevan is no stranger to advanced cell models…and their high-maintenance requirements. As a manager in the BioAnalytics applications group at Sartorius, Nicola and her team develop novel applications covering popular and emerging fields. We talked with her about induced pluripotent stem cell (iPSC)-derived cell therapies and the workflow challenges…

By Mike May, PhD Making therapies from induced pluripotent stem cells (iPSCs) usually takes many experiments to scale up production. Wei Xie, PhD, assistant professor of mechanical and industrial engineering at Northeastern University in Boston, hopes to streamline that process with modeling. Recently, Xie and her colleagues described a biological…

Starts undertaking quality evaluation and characterization of iPSCs in accordance with ISO standards PALO ALTO, Calif., Dec. 6, 2023 /PRNewswire/ — Leading GMP cell CDMO I Peace, Inc. (www.ipeace.com), specializing in induced pluripotent stem cells (iPSCs) and iPSC-derived cell therapies, announced that its Palo Alto quality control testing facility has been accredited…

Broadcast Date: December 19, 2023Time: 8:00 am PT, 11:00 am ET, 17:00 CET Genetic disorders such as cystic fibrosis and long QT syndrome are caused by mutations in human ion channel and ion transporter genes. Electroporation is a non-viral transfection technique increasingly used to study these disorders. Electric pulses cause transient permeability…

Abstract Discovery of genomic safe harbor sites (SHSs) is fundamental for multiple transgene integrations, such as reporter genes, chimeric antigen receptors (CARs), and safety switches, which are required for safe cell products for regenerative cell therapies and immunotherapies. Here we identified and characterized potential SHS in human cells. Using the…

Huang, X. et al. The landscape of mRNA nanomedicine. Nat. Med. 28, 2273–2287 (2022). Article  CAS  Google Scholar  Rohner, E., Yang, R., Foo, K. S., Goedel, A. & Chien, K. R. Unlocking the promise of mRNA therapeutics. Nat. Biotechnol. 40, 1586–1600 (2022). Article  CAS  Google Scholar  Brown, A., Shao, S.,…

Details Posted: 04-Dec-23 Location: Birmingham, Alabama Salary: Open Categories: Academic/Faculty Medical – Research Position Number: 01008 School/College: School of Medicine Job Description: THE OPPORTUNITY The University of Alabama at Birmingham (UAB) Department of Neurology is recruiting an investigator with expertise using human induced pluripotent cells (iPSCs) in Alzheimer’s disease research….

For the analyses, data from two patient iPSC lines, two parent iPSC lines and two unrelated control iPSC lines were pooled. A) Relative TXNL4A mRNA expression levels for patient iPSCs compared to mother iPSCs and unrelated control iPSCs, determined using qPCR of cDNA from each cell line. Graphs were obtained…

Market Overview and Report Coverage Induced pluripotent stem cells (iPSCs) are a type of stem cell that are artificially derived from mature, specialized cells through a process called reprogramming. These cells have the ability to self-renew and differentiate into various types of cells found in the human body. The future…

Abstract A major unmet need in the cystic fibrosis (CF) therapeutic landscape is the lack of effective treatments for nonsense CFTR mutations, which affect approximately 10% of CF patients. Correction of nonsense CFTR mutations via genomic editing represents a promising therapeutic approach. In this study, we tested whether prime editing,…

iPSCs Manufacturing Services Market Size, Share & Trends Analysis Report By Application (Research Products, Drug Development & Discovery, Cellular Therapy, Toxicology Screening, Personalized Medicine, Disease Modelling, Stem Cell Banking), By End-User, By Region, And Segment Forecasts, 2023-2031. The iPSCs Manufacturing Services Market Size is valued at 1095.8 Million in 2022…

Review doi: 10.1186/s11658-023-00504-2. Affiliations Expand Affiliations 1 Department of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35116, Egypt. hanymarei@mans.edu.eg. 2 Biomedical Research Center, Qatar University, 2713, Doha, Qatar. 3 Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, Qatar. Item in Clipboard Review Hany…

Tarawneh R, Holtzman DM. The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment. Cold Spring Harb Perspect Med. 2012;2(5): a006148. Article  PubMed  PubMed Central  Google Scholar  van der Flier WM, Scheltens P. Epidemiology and risk factors of dementia. J Neurol Neurosurg Psychiatry. 2005;76(suppl 5):v2-7. Article  PubMed  PubMed Central …

How regulatory t cells suppress the immune system?3 answersRegulatory T cells (Tregs) suppress the immune system through various mechanisms. One mechanism involves the suppression of cytotoxic T lymphocyte (CTL) responses, leading to a decrease in the production of cytokines such as IFN-γ and TNF by CD8+ T cells. Tregs also…

What is protocol of iPSC differentiation to Treg?5 answersThe protocol for iPSC differentiation into Treg cells is not mentioned in the abstracts provided. What prevents regulatory T cells from functioning properly in multiple sclerosis?5 answersRegulatory T cells (Tregs) in multiple sclerosis (MS) have been found to have defects in their…

At Sartorius, we offer a wide range of high-quality media and critical raw materials. We help you find the best formulation for your processes by offering expert support for media and services. Our comprehensive services, along with this, can help you quickly commercialize your product. Find out more and request…

A recent study published in Genome Biology has shed light on the profound effects of a loss-of-function mutation in the oxidation resistance 1 (OXR1) gene on neurodevelopment and cellular functions in the human brain. While OXR1 is known for its crucial role in oxidative stress resistance, the specific mechanisms and…

In recent years, advancements in technology have significantly transformed the landscape of drug discovery. One such groundbreaking innovation is induced pluripotent stem cell (iPSC) technology, which holds immense potential in accelerating the development of new therapeutic solutions. ​ This article delves into the ways iPSC technology is reshaping drug discovery…

Use Applied StemCell’s (ASC) new GMP facility, comprised of five cleanrooms equipped with cutting-edge technology, to develop the next generation of iPSC-derived therapeutics. We have dedicated cleanrooms for induced pluripotent stem cells (iPSC), mesenchymal stromal cells (MSC), chimeric antigen receptor T-cells (CAR-T), T-cell receptor-engineered T-cells (TCR-T), natural killer (NK) cells,…

Pluripotent stem cells (PSCs) have opened up new opportunities for the discovery and testing of therapeutic drugs and regenerative cellular therapies, contributing to our understanding of developmental biology. These cells are still not completely understood, despite the fact that PSC research has expanded quickly over the past 30 years, getting…

bit.bio, the company coding human cells for novel cures, and the Institute of Psychiatry, Psychology & Neuroscience today announce a collaboration to build multi-cell models of the human brain using bit.bio’s ioCells™️. Professor Deepak Srivastava and Dr Anthony Vernon Professor Deepak Srivastava and Dr Anthony Vernon will create different bi-…

Mice C57BL/6N (strain 005304), C3H/HeJ (strain 000659), FVB/NJ (strain 001800), BALB/cJ (strain 000651) and NSG mice (stock 005557) were purchased from the Jackson Laboratory. CD-1 (stock 022) mice were purchased from Charles River. Mice (6–20-week-old) of each strain/background were used for teratoma assays. Mice were housed in a pathogen-free facility…

1Federal University of Minas Gerais, Brazil The final, formatted version of the article will be published soon. Notify me Receive an email when it is updated You just subscribed to receive the final version of the article TNF-α is essential for induction and…

Global Induced Pluripotent Stem Cells (iPSCs) Market 2024-2031 Forecast: Strategic Insights and Data-Driven Growth Opportunities The most recent report on the “Induced Pluripotent Stem Cells (iPSCs) Market” provides an in-depth analysis of global trends, focusing on its various applications (Manufacturing, Academic Research, Drug Development And Discover, Toxicity Screening, Regenerative Medicine)…

Mutations in the SCN3A gene cause a spectrum of neurological conditions collectively referred to as SCN3A-related neurodevelopmental disorders, which includes different types of epilepsy and brain malformations. In a new study from researchers at Children’s Hospital of Philadelphia (CHOP), human induced pluripotent stem cell (IPSC) technology and gene editing were…

In a recent landmark study, scientists have reported successfully producing a live infant chimeric monkey of the species Macaca fascicularis. Representative individual shown above, April 23, 2022. | Photo Credit: Sharp Photography (CC BY-SA 4.0) At present, more than 3 lakh people are waiting for an organ transplant in India…

. 2023 Nov 8:S2213-6711(23)00415-0. doi: 10.1016/j.stemcr.2023.10.013. Online ahead of print. Affiliations Expand Affiliations 1 Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia. 2 Department of Anatomy & Developmental Biology, Monash University, Melbourne, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine…

The suitability of NK cells for cancer therapy has been challenged by some investor and business interests because of limited efficacy data, is this a valid belief at the present stage of development of the immune therapy field? NK cells are among the front line of protection from infected and…

iPSCs were generated from peripheral blood mononuclear cells (PBMCs), as previously described.7 PBMCs were isolated using Lymphocyte Separation Solution (Nacalai Tesque, Kyoto, Japan) and cultured in StemFitAK02N (Ajinomoto Healthy Supply, Tokyo, Japan) without supplement C containing 50 ng/mL human interleukin-6 (BioLegend, San Diego, CA), 100 ng/mL human stem cell factor (BioLegend), 10 ng/mL…

The suitability of NK cells for cancer therapy has been challenged by some investor and business interests because of limited efficacy data, but is this belief at the present stage of development of the immune therapy field? NK cells are among the front line of protection from infected and abnormal…

Cell therapy products in the U.S. are estimated to be worth approximately $4.5 billion currently and expected to grow to over $30 billion in the next ten years. As market value increases litigation is bound to heat up. Recently, Fate Therapeutics and the Whitehead Institute sued Shoreline Biosciences in the…

Supervisor: Professor Patrizia Ferretti Using human induced pluripotent stem cells (iPSCs) to study Down syndrome neural pathology and possible interventions Background:Down syndrome (DS) is the most common chromosomal abnormality in humans. Affected children have mental retardation and display premature onset of Alzheimer’s disease (AD). DS is a complex disease with…

Researcher & Professor at eCampus University Engineering Faculty. NASA Genelab AWG AI/ML member. Intellisystem Technologies Founder. getty AI researchers are exploring a promising “organoid intelligence” (OI) approach to develop more human-like intelligence. Researchers grow miniature brains from human stem cells to study brain development and neurological disorders. This emerging field…

The Global “Induced Pluripotent Stem Cells (iPSCs) Market” | Latest Research Report [2024-2031] offers an industry analysis that focuses on historical and future trends, industry segmentation by Types [Hepatocytes, Fibroblasts, Amniotic Cells, Cardiomyocytes, Others, ] and Applications [Manufacturing, Academic Research, Drug Development And Discover, Toxicity Screening, Regenerative Medicine]. It also…

PHILADELPHIA, PA — Century Therapeutics, Inc. (NASDAQ: IPSC) and FUJIFILM Cellular Dynamics, Inc. recently announced a new worldwide license agreement and expansion of existing licenses for the development and commercialization of cell therapies derived from iPSCs for the treatment of autoimmune and inflammatory diseases, including type 1 diabetes, multiple sclerosis,…

Asia-Pacific is now establishing itself as a global innovation hub, with China, Japan, and Korea leading the space in overall innovative pipeline assets in the region. The life sciences industry is thriving, and there has been a shift in the region from predominantly producing generics to developing innovative technologies, with…

Century Therapeutics, Inc. a clinical-stage biotechnology company developing induced pluripotent stem cell (iPSC)-derived cell therapies in immune-oncology, and FUJIFILM Cellular Dynamics, Inc., a global developer and manufacturer of human iPSCs and iPSC-derived cells, entered into a new worldwide license agreement and expansion of existing licenses for the development and commercialization…

1. Introduction As the world population ages, neurodegenerative diseases are increasing. The outcome of these diagnoses varies but can lead to fatality 50% of the time within 15–20 months [1]. Treatments for neurodegeneration, in particular motor neuron (MN) diseases, are restricted due to the limitations of motor neuron repair and…

PHILADELPHIA and MADISON, Wis., Nov. 09, 2023 (GLOBE NEWSWIRE) — Century Therapeutics, Inc. (NASDAQ: IPSC), an innovative clinical-stage biotechnology company developing induced pluripotent stem cell (iPSC)-derived cell therapies in immune-oncology, and FUJIFILM Cellular Dynamics, Inc., a leading global developer and manufacturer of human iPSCs and iPSC-derived cells, today announce a…

Highlights Karina Ascunce González graduated from Harvard University in May 2022 with an A.B. in Neuroscience and a secondary in Global Health & Health Policy Karina is currently a PhD Student in Biological and Biomedical Sciences, Neuroscience Track at Yale University. In addition to her PhD research, Karina is conducting…

Dublin, Nov. 08, 2023 (GLOBE NEWSWIRE) — The “Induced Pluripotent Stem Cell (iPSC) – Global Strategic Business Report” report has been added to ResearchAndMarkets.com‘s offering. The global market for Induced Pluripotent Stem Cell ((iPSC) estimated at US$1.8 Billion in the year 2022, is projected to reach a revised size of…

Review . 2023 Nov 7:33197231213192. doi: 10.1177/00033197231213192. Online ahead of print. Affiliations Expand Affiliations 1 School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou, China. 2 School of Basic Medical Sciences, Lanzhou University, Lanzhou, China. 3 Gansu Province Medical Genetics Center, Gansu Provincial Clinical Research Center for Birth Defects…

The advent of induced pluripotent stem cells (iPSCs) has opened a new frontier in personalized medicine. The well-politicized ethical challenges presented by fetal stem cells is no longer a barrier, if a patient’s own cells could be used. However, harnessing iPSCs for personalized medicine requires meticulous attention to quality control…

Abstract Pathogenic variants in the GNAO1 gene, encoding the alpha subunit of an inhibitory heterotrimeric guanine nucleotide-binding protein (Go) highly expressed in the mammalian brain, have been linked to encephalopathy characterized by different combinations of neurological symptoms, including developmental delay, hypotonia, epilepsy and hyperkinetic movement disorder with life-threatening paroxysmal exacerbations….

According to GlobalData’s Technology Foresights, which uses over 668,000 patents to analyze innovation intensity for the pharmaceutical industry, there are 80+ innovation areas that will shape the future of the industry. iPSCs is a key innovation area in cell & gene therapy Induced pluripotent stem cells (iPSCs) are a type…

Sci-Hub | In vitro Differentiation of ESCs/iPSCs to Myogenic Lineage: Moving towards Cell Therapy. Cellular & Molecular Medicine: Open Access, 01(01) | 10.21767/2573-5365.100009 ◂ ↓ save Hu, P. (2015). In vitro Differentiation of ESCs/iPSCs to Myogenic Lineage: Moving towards Cell Therapy. Cellular & Molecular Medicine: Open Access, 01(01). doi:10.21767/2573-5365.100009  10.21767/2573-5365.100009…

Induced pluripotent stem cells (iPSCs) have had a significant impact on understanding neurodevelopmental disorders. iPSCs provide a valid human test system to study disease-specific processes and mechanisms in vitro. They allow for the analysis of unique disease mechanisms and can be used for preclinical drug development. iPSCs have opened multiple…

Human induced pluripotent stem cells (iPSCs) Reprogramming and Culture This study was ethically approved by the Medical Ethics Committee of Nanjing Maternal and Child Health Care Hospital (2021KY-131), and informed consents were obtained from the patient’s legal guardian as well as the healthy donors, in accordance with the Declaration of…

Title: The Wonders of Stem Cells: Potential Applications and Ethical Considerations Introduction: Stem cell research has sparked great excitement within the scientific community due to its potential therapeutic applications and contributions to our understanding of human development. Stem cells possess the unique ability to differentiate into various cell types and…

AgeX Therapeutics Inc. is a biotechnology company that is at the forefront of a revolutionary scientific field known as cellular reprogramming. This cutting-edge technology has the potential to transform the field of regenerative medicine and has garnered significant attention from researchers and investors alike. Cellular reprogramming involves the conversion of…

Using iPS cells from I Peace, Heartseed succeeds in stable production of high purity cardiomyocytes I Peace, Inc., specialising in induced pluripotent stem cells (iPSCs) and iPSC-derived cell therapies based in Palo Alto, CA, and Heartseed Inc. a Tokyo-based biotechnology company developing iPSC-derived cardiomyocytes for heart failure, have collaborated to…

Researchers have improved the method of regenerating heart muscle after a heart attack using a combination of iPSC-derived cells. Researchers at the University of Wisconsin–Madison and Academia Sinica of Taiwan have utilised a combination of lab-grown cells to regenerate damaged heart muscle. The study addresses the challenges of using cardiomyocytes,…

Abstract The importance of glial cells, mainly astrocytes, oligodendrocytes, and microglia, in the central nervous system (CNS) has been increasingly appreciated. Recent advances have demonstrated the diversity of glial cells and their contribution to human CNS development, normal CNS functions, and disease progression. The uniqueness of human glial cells is…

doi: 10.1007/978-1-0716-3477-6_13. Affiliations Expand Affiliations 1 Department of Ecology, Environment and Plant Sciences (DEEP), Stockholm University, Stockholm, Sweden. 2 Umeå Plant Science Centre (UPSC), Department of Plant Physiology, Umeå University, Umeå, Sweden. 3 Department of Ecology, Environment and Plant Sciences (DEEP), Stockholm University, Stockholm, Sweden. edouard.pesquet@su.se. 4 Umeå Plant Science…

Explore applications of CRISPR and iPSCs in disease modeling and drug discovery in our upcoming webinar with Synthego and BrainXell. Standardizing cell models is essential for drug discovery and investigating mechanisms influencing disease onset. Using iPSC-derived neurons and glia marks a revolutionary shift in drug discovery, enabling direct study of…

A lack of robust genetic tools has hindered experiments in human primary macrophages. Gutierrez’s team developed a novel human macrophage cell model to dissect the role that autophagy plays in curtailing Mycobacterium tuberculosis (false colored here in green). Tony Fearns Mycobacterium tuberculosis (Mtb) and the human immune system have been at…

Human heart cells (green-and-red-striped bands in the lower half of the image) grafted into a nonhuman primate heart aside native heart cells (striped red without green). Mixing in the cells that line arteries with heart muscle has improved the grafts. Image By: Yu-Che Cheng Researchers at the University of Wisconsin–Madison…

iPSCs (induced pluripotent stem cells) are the best model to study Ribosomal Protein mutations because they can be generated from patient samples and differentiated into various cell types, including hematopoietic cells. This allows researchers to study the effects of Ribosomal Protein mutations on different cell types and understand the underlying…

Transcribed image text: 10) In the fast-growing field of regenerative medicine, the use of stem cells to regenerate or modify diseased tissues is an important advancement. Although the use of embryonic stem cells is very controversial, important research is ongoing towards the therapeutic use of induced pluripotent stem cells (iPSCs)….

In hiPSCs, researchers developed a strategy to prevent epigenetic aberrations caused by reprogramming. Human embryonic stem cells (ESCs), derived from the inner cell mass of the blastocyst before its attachment to the uterus, can differentiate into multiple cell types. Due to the ethical debate surrounding their use in research, scientists…

Rett syndrome is a rare devastating neurological disorder that primarily affects young girls and manifests as an impaired ability to walk and talk, along with characteristic ‘hand-wringing’ movements, seizures, and cognitive disability. This incurable condition results from mutations in the methyl-CpG binding protein 2 (MECP2) gene that impairs the role…

Join us for an informative webinar on creating induced pluripotent stem cells (iPSCs), which sheds light on the strengths of the mRNA technique compared to other methods. Discover the new Miltenyi Biotec mRNA reprogramming workflow and its myriad of benefits including enhanced efficiency, safety, and reproducibility in a streamlined process…

Abstract Epigenetic variation in the X chromosome inactivation (XCI) of human induced pluripotent stem cells (hiPSCs) can impact their ability to accurately model biological sex biases. However, the gene-wise landscape of escape from XCI remains unresolved in female hiPSCs. To characterize the patterns of escape from inactivation, we performed a…

The organoids grown from patients and controls differed in their expression of thousands of genes – in line with the finding that the genetic influences on schizophrenia are many and very small. However, among the genes, those associated with neuronal axons stood out as a group. Dr. Akkouh explained, “We…

Hedrick, S. M., Cohen, D. I., Nielsen, E. A. & Davis, M. M. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 308, 149–153 (1984). Article  CAS  PubMed  Google Scholar  Yanagi, Y. et al. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains….

The rapidly expanding market for regenerative medicines and cell therapies highlights the need to advance the understanding of cellular metabolisms and improve the prediction of cultivation production process for human induced pluripotent stem cells (iPSCs). In this paper, a metabolic kinetic model was developed to characterize underlying mechanisms of iPSC…

Other Title (Parallel Title in Other Language of ETD) ผลการกลายพันธุ์ของยีน JAK2 ต่อกระบวนการสร้างเม็ดเลือดแดงโดยใช้เทคนิคเซลล์ต้นกำเนิด First Advisor Ponlapat Rojnuckarin Second Advisor Nipan Israsena Faculty/College Faculty of Medicine (คณะแพทยศาสตร์) Degree Name Doctor of Philosophy Degree Level Doctoral Degree Degree Discipline Medical Sciences DOI 10.58837/CHULA.THE.2019.365 Abstract Activating mutations affecting the JAK-STAT signal transduction is the…

Induced Pluripotent Stem Cells (iPSc) Market Analysis and Latest Trends Induced Pluripotent Stem Cells (iPSCs) are a type of stem cell that can be generated from adult cells, such as skin cells, by reprogramming them to behave like embryonic stem cells. These cells have the potential to develop into any…

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are…