404 Not Found – ROMA BOOTS

IN 12 YEARS ROMA HAS DONATED 10 MILLION DOLLARS WORTH OF BOOTS IN 30+ COUNTRIES AROUND THE WORLD. We’re sorry, but the page you requested could not be found. Subscribe Sign up to get the latest on sales, new releases and more … /* =============================================== // Reveal module // ===============================================…

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Link between breast implants after mastectomy, risk of lymphoma: Research | Health

Anaplastic large-cell lymphoma (ALCL) is a rare disease whose incidence has increased recently; this increase may be related to the expanding popularity of textured breast implants. Some breast cancer patients who have mastectomy may question whether the advantages of receiving reconstructive implants outweigh the possibility of having a second cancer…

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We conclude that the 18S stem-loop structure is recognized at least twice during pre-rRNA processing.

Abstract ABSTRACT The loop of a stem structure close to the 5′ end of the 18S rRNA is complementary to the box A region of the U3 small nucleolar RNA (snoRNA). Substitution of the 18S loop nucleotides inhibited pre-rRNA cleavage at site A1, the 5′ end of the 18S rRNA,…

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CD44 promotes angiogenesis in myocardial infarction through regulating plasma exosome uptake and further enhancing FGFR2 signaling transduction

Background: Since angiogenesis occurs as the pathological process following myocardial infarction to alleviate ischemia, therapeutic angiogenesis has been proposed to be a cardioprotective strategy. CD44 has been implicated in endothelial cell functions and its role has been well established in angiogenesis for years. Although recent studies indicate the close correlation…

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Compressing BAM, SAM, CRAM | Genozip

How good is Genozip at compressing BAM files? ​ See Benchmarks. ​ Compressing a BAM, SAM or CRAM file  ​ In the rest of this page we will give examples of BAM files. Genozip is also capable of compressing SAM files, and with some limitations, CRAM files as well. ​…

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Role of STING protein in breast cancer: mechanisms and therapeutic implications

Review doi: 10.1007/s12032-022-01908-4. Affiliations Expand Affiliations 1 Department of Vascular and Endocrine Surgery, Xijing Hospital, The Air Force Medical University, Xi’an, 710000, China. 2 Department of Vascular and Endocrine Surgery, Xijing Hospital, The Air Force Medical University, Xi’an, 710000, China. vascularzhang@outlook.com. Item in Clipboard Review Yue Jiang et al. Med Oncol….

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genbank sequence format

HHS Vulnerability Disclosure, Help This document is an overview of the Entrez databases, with general information on If you are not sure that the “Save” option in your program will do this for you, use “Save As”, In Excel, select “Save As” from the File menu. optimizations to reduce memory…

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Genetic genealogy ‘game changer’ offers hope for near-unsolvable Ontario cold cases

“Now that we have the killer’s DNA, we just need a name to go with it.” “Forensic testing was done and DNA was identified, but it does not link to any known offenders in the national DNA data bank.” “While the offender is not on the national DNA data bank,…

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LJ Potential Parameters – LAMMPS General Discussion

Hello!Can anyone help me with how to find LJ potential parameters for Lammps? Suppose I want to know LJ parameters for h-BN structure simulation in lammps! I seriously doubt that a set of Lennard-Jones parameters will create a good representation of your system. You will either need a more complex…

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Error when Installing BioConductor Package (‘affy’)

Hi, when I try to install Bioconductor package ‘affy’ Experience below error\ May I know how do I fix this? I’m currently using R4.2.2 on MacBook Air, M1\ R version 4.2.2 (2022-10-31) — “Innocent and Trusting”\ Copyright (C) 2022 The R Foundation for Statistical Computing\ Platform: aarch64-apple-darwin20 (64-bit) BiocManager::install(“affy”) ‘getOption(“repos”)’…

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Espressif’s Ali Hassan Shah Walks Through Putting a TinyML Gesture Recognition Model on an ESP32-S3

Espressif’s Ali Hassan Shah has penned a guide to getting started with the company’s ESP-DL TinyML edge AI framework, using it to deploy a gesture recognition model on to an ESP32-S3 microcontroller. “Artificial intelligence transforms the way computers interact with the real world. Decisions are carried by getting data from…

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EMDB < EMD-20433

Field: Choose…EMDB IDTitleAuthorORCIDEM methodCurrent statusDeposition dateRelease dateDeposition siteLast processing siteFitted modelsRaw dataResolutionResolution methodSoftwareLigand nameComplex nameDomain nameDrug nameGO term nameInterPro term nameChEBI term nameExternal reference Publication titlePublication yearJournalPublication author Sample typeSample nameOrganismOrganism (NCBI code)StrainOrganTissueCellOrganelleCellular LocationE.C. numberMolecular Weight methodMolecular Weight (Da)Recombinant ExpressionRecombinant organismRecombinant organism (NCBI code)Recombinant strainRecombinant expression cellRecombinant expression plasmidDNA/RNA classificationDNA/RNA…

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Differentially expression analysis of orthologous genes between two species

Differentially expression analysis of orthologous genes between two species 1 @4dbfec5b Last seen 10 hours ago Netherlands Hi people, I want to use DESeq2 for differentially expression analysis of orthologous genes between two different species. I am not experienced at all using R and DESeq2, but I think at the…

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TDF to bed graph — IGV on command line

TDF to bed graph — IGV on command line 0 Hi all, I’m trying to convert some TDF files to bedgraph files so that I can do a genomic leftover on them (as far as I can tell, I can’t lift over TDF files). This google group answer here (groups.google.com/g/igv-help/c/RcZw5YB5SOQ)…

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“Our generation will see an artificial intelligence that equals or exceeds that of the human being”

since he saw as a child 2001: A Space Odyssey, Oriol Vinyals knew that he wanted to dedicate himself to artificial intelligence. “I was very interested in how naturally Hal 9000, the computer, spoke. Could we achieve something like this?”, this teenager from Sabadell was already wondering. Today, at 39,…

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Financial Contrast: MaxCyte (NASDAQ:MXCT) vs. Protalex (OTCMKTS:PRTX)

MaxCyte (NASDAQ:MXCT – Get Rating) and Protalex (OTCMKTS:PRTX – Get Rating) are both medical companies, but which is the better stock? We will compare the two businesses based on the strength of their analyst recommendations, valuation, earnings, dividends, institutional ownership, risk and profitability. Analyst Recommendations This is a breakdown of…

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Genome Bioinformatics Analyst at UPMC

Description The Genome Bioinformatics Analyst works independently to curate disease, gene and variant knowledge including variant interpretation, reporting and consultation with laboratory staff, physicians and genetic counselors. The analyst participates in clinical test development, validation and maintenance of data analysis pipelines, monitoring of quality metrics and the analysis of large…

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Post-doc in Computer Science / Bioinformatics – University of Bern – job portal

Post-doc in Computer Science / Bioinformatics We are seeking to hire a person with a PhD in bioinformatics, computational biology, data science, computer science, statistics or applied mathematics. Preferably the candidate should have experience of using large data sets to undertake projects with a particular focus on the integration of…

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19 Vacancies, Check Posts, Eligibility and Other Details

DRDO-DFRL Recruitment 2022: 19 Vacancies, Check Posts, Eligibility and Other Details DRDO-DFRL Recruitment 2022: The Defence Food Research Laboratory (DFRL) is an Indian defence laboratory of the Defence Research and Development Organisation (DRDO), located in Mysore, Karnataka. It conducts research and development of technologies and products in the area of…

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Biochemical characterization of the two novel mgCas12a proteins from the human gut metagenome

Discovery of 11 new Cas12a candidates from a human gut microbiome database To discover new members of the Cas12a protein family, we built a pipeline that searches and sorts out new candidates from the National Center for Biotechnological Information (NCBI) human metagenome database. Using this search pipeline (Fig. 1a), we initially…

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recommend tools for scRNAseq cell type annotation

recommend tools for scRNAseq cell type annotation 1 Dear all, May I know if there are recommended tools/webs for the cell type annotation? Say, I have the cell expression matrix, and want to generate a cell type/labels file based on the expression matrix and the prior knowledge of the cell…

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A strategy to thermally stabilize microneedle vaccine technology

Credit: Thanh Nguyen/University of Connecticut Researchers in the Department of Biomedical Engineering—a shared department between the UConn Schools of Dental Medicine, Medicine, and Engineering—unlocked a new strategy using sugar molecules to thermally stabilize their existing microneedle vaccine technology, eliminating the need for cold-chain storage. Associate Professor Thanh Duc Nguyen from…

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Bioinformatics Services Market Size, Growth, Share-Global Trends, Market Demand, Development Status, Growth Opportunities and Forecast 2028

A quantitative analysis of regional markets is combined with a fresh perspective on the target industry in the Bioinformatics Services Market study. The research covers market size, drivers and weaknesses, key players, a sector overview, and a geographic forecast, among other topics. It also contains information on the business climate,…

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Bar chart not coming in the desirable way – tidyverse

Hi,I have a data for tracking attendance of teachers. In the sample data I have given the variable attendance. 1 means attended and 2 means absent. Now I need to get a bar chart where I get the Instructors name on the X-axis and the average attendance % on the…

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ggplot2 – remove NA’s from only one Variable in scatter plot with 2 variables over time in R / ggplot

I want to plot 2 variables over a time period with ggplot. One of the variables contains NAs. I want to drop the NAs from the plot without losing the value for the other variable. Right now, ggplot plots all NAs in a line at the top of the y-axis….

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Page Not Found – Jupyter Community Forum

Sign Up Log In Log In Popular Official Mastodon account(s)?Meta 403 Forbidden Error when using Azure AD for authenticationZero to JupyterHub on Kubernetes Install pip package such as backtrader in the jupyter/datascience-notebook imagediscuss error to download file in jupyterhub – failed – network errorJupyterHub [ANN] Jupyter Core 5.0Meta [ANN] New…

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Solved 2. Nucleic acids ( 5 points) a. In the Sanger

Transcribed image text: 2. Nucleic acids ( 5 points) a. In the Sanger (dideoxy) method for DNA sequencing, a small amount of dideoxynucleotides triphophosphate-say, ddCTP – is added to the sequencing reaction along with a larger amount of corresponding JCTP. i. What is the function of the ddCTP (i.e., why…

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RStudio fails to start up after update to latest version and update of R to 4.2.2 – RStudio IDE

Error Information: Nothing visibleDescription of issue –Updated R and Rstudio after not using it since 2017 (although that version worked)R Works OKRStudio fires up icon then immediately fails with a segmentation fault Attempted steps taken to fix –Deleted all RStudio files and then re-downloaded RStudio . System Information: RStudio Edition:…

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KSUM to organise bootcamp for SaaS startups

The Kerala Startup Mission (KSUM) will be conducting a two-day free bootcamp for start-ups on December 10. The camp is being organised in association with CareStack at its office in Technopark Phase-3 here. Founders and leaders of CareStack, a startup which develops SaaS (Software as a Service) products, will lead the bootcamp….

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Guided exercises to practice ATAC-seq/ChIP-seq analysis?

Guided exercises to practice ATAC-seq/ChIP-seq analysis? 1 Hello everyone! I was wondering if there is any way to practice ATAC-seq/ChIP-seq analysis with guided exercises. Do you know of any resource? RNA-seq would be great too, although I have seen many of them online, if there is any particularly good resource,…

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Metagenomics Maps How the Gut Microbiome Is Altered in Parkinson’s Disease

New research from the University of Alabama at Birmingham says the gut microbiome is involved in multiple pathways in the pathogenesis of Parkinson’s disease. The findings, published in Nature Communications, show a wide imbalance in microbiome composition in persons with Parkinson’s disease. The study is the largest microbiome study conducted at the highest…

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Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil | Malaria Journal

WHO. World Malaria Report. Geneva: World Health Organization; 2019. Google Scholar  Rogerson SJ, Hviid L, Duffy PE, Leke RF, Taylor DW. Malaria in pregnancy: pathogenesis and immunity. Lancet Infect Dis. 2007;7:105–17. Article  CAS  PubMed  Google Scholar  Salanti A, Dahlback M, Turner L, Nielsen MA, Barfod L, Magistrado P, et al….

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PRC2 direct transfer from G-quadruplex RNA to dsDNA: Implications for RNA-binding chromatin modifiers

Abstract The chromatin-modifying enzyme, Polycomb Repressive Complex 2 (PRC2), deposits the H3K27me3 epigenetic mark to negatively regulate expression at numerous target genes, and this activity has been implicated in embryonic development, cell differentiation, and various cancers. A biological role for RNA binding in regulating PRC2 histone methyltransferase activity is generally…

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With CRISPR gene scissors in opposition to HIV: First try is underway within the USA

With CRISPR gene scissors in opposition to HIV: First try is underway within the USA On December 1st, World AIDS Day, information from the USA presents hope for these affected. In July 2022, the Californian biotech firm Excision BioTherapeutics dared to make use of a brand new remedy idea with…

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About: Mir-194 microRNA precursor family

In molecular biology, miR-194 microRNA precursor is a small non-coding RNA gene that regulated gene expression. Its expression has been verified in mouse (MI0000236, MI0000733) and in human (MI0000488, MI0000732). mir-194 appears to be a vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate…

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Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis

Wang, J., Garancher, A., Ramaswamy, V. & Wechsler-Reya, R. J. Medulloblastoma: from molecular subgroups to molecular targeted therapies. Annu. Rev. Neurosci. 41, 207–232 (2018). Article  CAS  PubMed  Google Scholar  Cavalli, F. M. G. et al. Intertumoral heterogeneity within medulloblastoma subgroups. Cancer Cell 31, 737–754.e736 (2017). Article  CAS  PubMed  PubMed Central …

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A high-throughput multispectral imaging system for museum specimens

The two-dimensional nature of many pinned Lepidoptera specimens allows us to omit some technical considerations, such as the variable incident angles that need to be carefully considered when imaging 3D objects, and our multi-spectral imaging rig with its custom designed platform can image both the dorsal and ventral sides of…

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RNAi for Therapeutic Market May See a Big Move | Moderna, BOC Sciences, Abogen Biosciences

Latest Study on Industrial Growth of RNAi for Therapeutic Market 2022-2027. A detailed study accumulated to offer Latest insights about acute features of the RNAi for Therapeutic market. The report contains different market predictions related to revenue size, production, CAGR, Consumption, gross margin, price, and other substantial factors. While emphasizing…

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Possible bugs in Rsubread/stad-alone featureCounts options fracOverlap and largestOverlap with fractional counts

Hi, running Rsubread 2.8.2/2.12.0 or featureCounts 2.0.3/2.0.1, I stumbled over two issues when allowing ambiguous read assignment (-O/allowMultiOverlap) 1) regarding assignment via minimum fractional overlap (–fracOverlap) using featureCounts stand-alone binary. 2) when combined with –/largestOverlap and –/fraction using Rsubread featureCounts function or the stand-alone binary. to 1) Assume a read…

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Copy number variations in patients with idiopathic recurrent pregnancy loss: an array-CGH approach

Copy number variations in patients with idiopathic recurrent pregnancy loss: an array-CGH approach Atıf İçin Kopyala Yildiz O., SILAN F., Karakaya T., Özdemir Ö. Turkish Journal of Medical Sciences, cilt.52, sa.5, ss.1689-1696, 2022 (SCI-Expanded) …

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The Promise of RNA-Based Therapies

Published a day ago Submitted by CRB Decades of scientific progress in understanding the root cause of many formerly intractable diseases has opened up new treatment options, namely through RNA-based therapies. This second wave of biopharma, in which our understanding of the ways coding portions of our genome relate to…

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AWS launches Amazon Omics for precision medicine

To enhance clinical insights at the point of care and help identify the best treatment or prevention options for patients, Amazon Web Services has launched a service that utilizes artificial intelligence (AI), machine learning, and other AWS and partner products and services to run IT-heavy bioinformatics workflows.  WHY IT MATTERS…

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How can I calculate PRS for all samples by using PRSice-2.

How can I calculate PRS for all samples by using PRSice-2. 0 Hi. I am trying to calculate PRS by using PRSice-2. I’d like to know how to handle the model. When I provide same gwas results to PRSice-2’s –base option, is the model always same? I have several thousands…

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Some People More Prone to COVID-19 Vaccine Side Effects

Among individuals who have received COVID-19 vaccines, younger people, females, and those who got the second dose of the Moderna COVID-19 vaccine report more side effects from COVID-19 vaccines that may have led to moderate and severe limitations, according to a recent paper (Front Public Health 2022; doi: 10.3389/fpubh.2022.975781). These…

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Changes in Protein Structure May Act as Parkinson’s Biomarkers | Potential for Easier Diagnosis in Analysis of Protein Shape

Changes in the structure of 76 proteins in the cerebrospinal fluid (CSF) of people with Parkinson’s disease were seen when compared with those of healthy individuals, a study reported. Its researchers believe their work is the first to look at protein structure — rather than abundance — to identify potential new…

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Where to find vcf of dbsnp build 144 ?

Where to find vcf of dbsnp build 144 ? 0 Hi everyone, I have zipped vcf files that I would like to annotate using hg19 bsnp144. I have bed files for each chromosome but, based on other biostar answers (How to add rsIDs to VCF?), it seems it is easier…

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Makeblastdb – ECHEMI

0  Upvotes · 5 Comments 0  Upvotes · 1 Comments 0  Upvotes · 1 Comments 0  Upvotes · 2 Comments 0  Upvotes · 2 Comments 0  Upvotes · 6 Comments 0  Upvotes · 12 Comments Read more here: Source link

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dharmacon sirna design

Please feel free to visit our Privacy Policy and Cookie Policy with regards to processing your data. Article Customer Support Sequence characteristics of functional siRNAs. Human and mouse genes are each targeted with multiple shRNA constructs that have been cloned into the pGIPZ lentiviral vector. GRCF Management Team. In the…

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biology questions – hw 2.docx – 1) The red blood cells in your body are going through the process of transcription. What are the enzymes needed to make

1)The red blood cells in your body are going through the process of transcription. What arethe enzymes needed to make rRNA and the basic steps in which this process occurs?A)A ‘specific’ transcription factor binds to the promoter region and allows RNA PolymeraseI to read the DNA and create rRNA.B)A ‘specific’…

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The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers

Cite this Article How to cite Lu L, Liu Y, Zhang G, Xu Y, Hu D, Ji G, Xu H, . The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers. Aging (Albany NY). 2022 Nov 29; . doi.org/10.18632/aging.204406 [Epub ahead of print] Copy or Download citation:…

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scikit learn – Importing sklearn in Databricks downgrades the Python root logger?

Using Python 3.8.10 in an Azure Databricks notebook, runtime 10.4: >>> import logging >>> type(logging.root) logging.RootLogger Ok, that was expected. What’s surprising is this: >>> import sklearn # version is 1.1.3 >>> import logging >>> type(logging.root) numpy.distutils.log.Log This is problematic because numpy’s Log is not as powerful as Python’s; in…

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Datasets | TogoVar

Variant frequencies for which you can apply for use of individual-level data∗1 to the NBDC human databases∗2 Click the links at the Included controlled-access datasets to apply for use of individual-level data ∗1:fastq/bam/cel files and/or lists of genotype data etc.∗2:Japanese Genotype-phenotype Archive (JGA) / AMED Genome group sharing Database (AGD)…

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query regarding error in installation of “goseq” R bioconductor package

query regarding error in installation of “goseq” R bioconductor package 0 @6d5973d2 Last seen 19 hours ago India I am trying to install “goseq” Bioconductor package in Rstudio (version- RStudio 2022.07.2 Build 576 ) on my system I have installed R version- 4.2.2 I getting many error messages which are…

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What Is Stem Cell Research?

There are cells within our bodies that have a spectacular power. Known as stem cells, they build our bodies before we’re born and regenerate our tissues to keep us alive. For example, stem cells in the skin help us heal from cuts and other stem cells deep in the bone…

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r – Cannot Install maftools into BiocManager due to RSQLite

I am a relatively new R-user. I am currently working on trying to read .maf files via the maftools package released by Bioconductor. I am following the instructions as posted on the Bioconductor website (www.bioconductor.org/packages/devel/bioc/vignettes/maftools/inst/doc/maftools.html#4_Installation), however, everytime I attempt to run the installation, it gets stuck on RSQLite and I…

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Evolutionary origins of the prolonged extant squamate radiation

Jones, M. E. H. et al. Integration of molecules and new fossils supports a Triassic origin for Lepidosauria (lizards, snakes, and tuatara). BMC Evol. Biol. 13, 208 (2013). Article  PubMed  PubMed Central  Google Scholar  Pyron, R. A., Burbrink, F. T. & Wiens, J. J. A phylogeny and revised classification of…

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Derazantinib Shows Clinical Benefit, Manageable Safety Profile in Patients With Cholangiocarcinoma

Derazantinib is an investigational oral inhibitor of FGFR1, FGFR2, and FGFR3 in patients with locally advanced or metastatic intrahepatic cholangiocarcinoma. Treatment with derazantinib, an FGFR inhibitor, produced a meaningful clinical benefit with a manageable safety profile in patients with locally advanced or metastatic intrahepatic cholangiocarcinoma (iCCA), according to data from…

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The Accept Phase Ib/II Single Arm Study

Oral and Poster Abstracts 626. Aggressive Lymphomas: Prospective Therapeutic Trials: Poster III Research, clinical trials, Lymphomas, Clinical Research, Combination therapy, Diseases, aggressive lymphoma, Therapies, Lymphoid Malignancies Andrew J Davies, BSc, BM, FRCP, PhD1,2*, Josh Caddy, BSc3*, Katy McLaughlin, BSc3*, Christopher Wignall, MSc3*, Robert…

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What does RFLP stand for? (Multiple Choice Quiz)

What does RFLP stand for? (Multiple Choice Quiz) This is a List of Available Answers Options : restriction fragment length palindromes ribose fragment lactose phosphates restriction fragmentation ligase polymorphs restriction fragment length polymorphisms The best answer is D. restriction fragment length polymorphisms. Reported from teachers around the world. The correct…

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DashBio Alignment Chart/Sequence Viewer – Dash Python

Hello,I am using dash bio to view multiple sequences that are read from a Fasta file. Everything seems to work fine but I am wondering if there is a way to change the numbering that appears at the bottom of the sequence chart. The sequences I am reading follow a…

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Programmable CRISPR-Based Tool ‘Pastes’ in New Genes While Avoiding Double-Strand Breaks

NEW YORK — Researchers at MIT have developed a programmable tool that combines CRISPR and integrases to cut out unwanted stretches of DNA and paste in a replacement. While CRISPR-Cas9 gene editing can make such swaps, it is limited by the need for double-stranded DNA breaks, which can induce undesired…

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A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias

CRISPR/Cas gene drives can bias transgene inheritance through different mechanisms. Homing drives are designed to replace a wild-type allele with a copy of a drive element on the homologous chromosome. In Aedes aegypti, the sex-determining locus is closely linked to the white gene, which was previously used as a target…

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Phase 1 Trial to Test ‘Off-the-shelf’ CAR T-cell Therapy CB-011 in 2023 | CAR T-cell Therapy CB-011 to Be Tested in Hard-to-treat Myeloma in 2023

Caribou Biosciences will soon start testing its new CAR T-cell therapy candidate, CB-011, in people with relapsed or refractory multiple myeloma. A Phase 1 trial will begin enrolling eligible adults in early 2023 at multiple centers, according to the company. The announcement follows clearance of the company’s investigational new drug…

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Characterization, genome analysis and genetic tractability studies of a new nanocellulose producing Komagataeibacter intermedius isolate

Isolation, characterization and classification of BC-producing strain Isolation of single clones from CaCO3 halo zones in Glucose-Yeast Extract-Calcium carbonate agar and iterated subculturing in HS-Glu agar resulted in enrichment of an isolate with beige-coloured, smooth-edged and umbonate shaped colonies characteristics (Fig. S1A). The isolate is hereafter called ‘ENS15’. Under 100X magnification,…

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Scatter Gather principle by chromosome on Gatk

Scatter Gather principle by chromosome on Gatk 0 Hi all, On a quest to optimize gatk pipeline, I met scatter gather principle, so I did following, pids= for chr in chr1 chr2 chr3 chr4 chr5 chr6 chr7 chr8 chr9 chr10 chr11 chr12 chr13 chr14 chr15 chr16 chr17 chr18 chr19 chr20…

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The Shape Of Proteins In Spinal Fluid Could Diagnose Parkinson’s Disease

Parkinson’s disease is on the rise as average ages increase, but treatment is often delayed through difficulties in distinguishing its early symptoms from other conditions. The discovery that proteins in a patient’s spinal fluid have distinctive structures could address this problem. It could also increase our understanding of the causes…

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This Python Library ‘Imitation,’ Provides Open-Source Implementations of Imitation and Reward Learning Algorithms in PyTorch

In areas with clearly defined reward functions, like games, reinforcement learning (RL) has outperformed human performance. Unfortunately, it is difficult or impossible for many tasks in the real world to design the reward function procedurally. Instead, they must immediately absorb a reward function or policy from user feedback. Furthermore, even…

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Amoxicillin and thiamphenicol treatments may influence the co-selection of resistance genes in the chicken gut microbiota

General description of sequences After the quality filtering step, removal of chimeric fragments, and read merging, a total of 3,378,323 reads with 3007 different features was obtained, with an average of 27,244 sequences per individual sample. After quality filtering, none of the samples was excluded from the analysis of microbial…

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Backpropagation Network using Python

Backpropagation neural network is used to improve the accuracy of neural network and make them capable of self-learning. Backpropagation means “backward propagation of errors”. Here error is spread into the reverse direction in order to achieve better performance. Backpropagation is an algorithm for supervised learning of artificial neural networks that…

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Control-FREEC output

Control-FREEC output 0 Hello everybody, I’m using the tool Control-FREEC to evaluate the CNVs in my data, but I have some doubts about the _ratio.txt file in output. As far as I understood by both the paper and the documentation, this file should report the ratio (that, if I’m correct,…

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Incorporating molecular markers in standard prognostic models for DLBCL patients using real-world data.

Remember all your deadlines for grant applications and conference abstracts! Add your email to join our free beta test: Stage (stratigraphy) Hazard ratio Population e19251 Background: NCCN-IPI is a prognostic scoring system that outperforms other risk classification mechanisms in diffuse large B-cell lymphoma (DLBCL) but does not consider the molecular…

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Getting information on CRAM files from headers inside the files

Getting information on CRAM files from headers inside the files 1 Hello. I wish to know if one can find the following information in CRAM files’ headers: 1) Whether or not sequencing data in CRAM files is from WGS or WES, and if so, where? and 2) In case one…

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Page not found at /datasources/?sort=file_type

Page not found at /datasources/?sort=file_type Using the URLconf defined in tadeus_portal.urls, Django tried these URL patterns, in this order: [name=”index”] moj [name=”index2″] tracks/ help/ plots/ browser/ ontologies/ datasources/ [name=”index”] datasources/ create/<p_type> [name=”create”] datasources/ <int:p_id> [name=”update”] datasources/ <int:p_id>/delete [name=”delete”] evaluation/ admin/ api/ The current path, datasources/?sort=file_type, didn’t match any of these….

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[slurm-users] How to launch slurm services after installation

Hello, all supported build flags are available with “./configure –help” command. On of them is “–with-systemdsystemunitdir=DIR”, which will allow you to specify the directory for the systemd service files for all Slurm daemons. The most important of the flags is imho the “–prefix”, which sets the installation directory. I’ll describe my build setup shortly…

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Unexpected absence of ribosomal protein genes from metagenome-assembled genomes

Hug LA, Baker BJ, Anantharaman K, Brown CT, Probst AJ, Castelle CJ, et al. A new view of the tree of life. Nat Microbiol. 2016;1:16048. Article  PubMed  Google Scholar  Castelle CJ, Wrighton KC, Thomas BC, Hug LA, Brown CT, Wilkins MJ, et al. Genomic expansion of domain archaea highlights roles…

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Cryptic Cython Error Message – ASKSAGE: Sage Q&A Forum

I have been coding a basic algorithm to compute infinite dimensional path integrals in cython cell in sagemath and have received an error message I am completely baffled by. Despite a good amount of effort I can not reproduce this in a short code sequence. I don’t expect anyone to…

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Integrated taxonomy reveals new threatened freshwater mussels (Bivalvia: Hyriidae: Westralunio) from southwestern Australia

Genetic variation The best fitting substitution models for COI codons 1–3 were identified as TN + F + G4, F81 + F + I, and TN + F, respectively. The maximum likelihood (ML) and Bayesian inference (BI) trees showed similar topologies of the main nodes, although the BI tree displayed greater resolution of the ingroup branches (Fig. 1). Furthermore, the BI…

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Now, changing forms of Covid 19 can be examined right here in city

Indore (Madhya Pradesh): The mutating variants of coronavirus, which had played havoc during its second wave in the country last year, can now be investigated in the city as the much-awaited genome sequencing machine has reached Mahatma Gandhi Memorial Medical College. “This state-of-the-art machine has been received from the World…

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Problem while running NEB, neb style ‘each’ – LAMMPS General Discussion

Hello everyoneI am sorry if the question is so bacis, acutally I am facing problem while running NEB and using the file style ‘each’. The calculation don’t run with the error of ‘Illegal NEB command (src/REPLICA/neb.cpp:124)’.I have all replicas initial configurations present in the directory and here is the simplest…

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Gromacs: nbnxn_sci Struct Reference

#include <gromacs/nbnxm/pairlist.h> Description Grouped pair-list i-unit. Public Member Functions int  numJClusterGroups () const   Returns the number of j-cluster groups in this entry.   Public Attributes int  sci   i-super-cluster   int  shift   Shift vector index plus possible flags.   int  cjPackedBegin   Start index into cjPacked.   int …

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1. Which Chinese Dynasties limited their trade with

1. Which Chinese Dynasties limited their trade with the Mongols? Why is this seen as contributing to the eruption of the Mongol Invasions? What two other features are generally thought to have contributed to the eruption?2. What is seen as the main reason why Gengis Khan’s sons and grandsons took…

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Bug#1024835: python-pauvre: ftbfs with biopython 1.80

Source: python-pauvre Version: 0.2.3-1 Severity: important Tags: ftbfs Dear Maintainer, python-pauvre fails its build time test suite when built against biopython 1.80 in experimental but builds successfully against biopython 1.79. The relevant part of the log in case of failure shows: I: pybuild base:240: cd /<<PKGBUILDDIR>>/.pybuild/cpython3_3.10_pauvre/build; python3.10 -m unittest discover -v test_normal_plotting_scenario (pauvre.tests.test_synplot.libSeq_test_case) This…

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Bioconductor – EasyCellType

DOI: 10.18129/B9.bioc.EasyCellType     Annotate cell types for scRNA-seq data Bioconductor version: Release (3.16) We developed EasyCellType which can automatically examine the input marker lists obtained from existing software such as Seurat over the cell markerdatabases. Two quantification approaches to annotate cell types are provided: Gene set enrichment analysis (GSEA)…

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Molecular Modeling Software for Chemistry Market Booming Worldwide With Leading Key Players -ChemDoodle, ChemAxon, Hypercube, ACD/ChemSketch, Avogadro, MolView, BIOVIA Draw

The latest research on “Molecular Modeling Software for Chemistry Report 2022” offered by MRA provides a comprehensive investigation into the geographical landscape, industry size along with the revenue estimation of the business. Additionally, the report also highlights the challenges impeding market growth and expansion strategies employed by leading companies in…

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Problem to open autodock

Problem to open autodock 0 Hey everyone, I need to do a torturial for docking for my study. I want to try it via autodock but I get every time after installing this following window from phython when I want to open AutodockTools. Type “copyright”, “credits” or “license()” for more…

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509 Bandwidth Limit Exceeded

509 Bandwidth Limit Exceeded The server is temporarily unable to service your request due to the site owner reaching his/her bandwidth limit. Please try again later. Read more here: Source link

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Can you pass on COVID-19 if you’re testing negative?

Yes, it is possible to still spread COVID-19 if you test negative but have cold-like symptoms. This is true if you just started having symptoms, as well as if you’re testing negative after a COVID-19 infection. Rapid COVID-19 tests are quite good at telling if someone is infected and can…

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Versatile and efficient genome editing with Neisseria cinerea Cas9

PAM identification of NcCas9 by PAM-DOSE The type II-C Cas9 orthologue NcCas9 is of small size (1082 aa) and is closely related to conventional Neisseria meningitidis Cas9 (NmeCas9)11 (Fig. 1a). The NcCas9 is 94% identical to Nme1Cas9, and the divergences lie mainly in the C-terminal PAM-interacting domain (PID) (Fig. 1a and S1)….

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why do i get much more significant genes and wierd volcano plot with DESeq2 for my RNAseq dataand LRT not with Walds test

I’m looking into the differentially expressed genes in heat-stressed animals versus normal ones. I have a data matrix of 40 samples of different conditions and using contrast I compare each one to its the control. I want to look at the heat stressed the other 3 are non-stressed old versus…

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AI Tailors Artificial DNA for Future Drug Development

With the help of an AI, researchers at Chalmers University of Technology, Sweden, have succeeded in designing synthetic DNA that controls the cells’ protein production. The technology can contribute to the development and production of vaccines, drugs for severe diseases, as well as alternative food proteins much faster and at…

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BCG Attorney Search hiring Bioinformatics Technical Specialist, Patent Agent in Washington, District of Columbia, United States

Washington, D.C. office of a BCG Attorney Search Top Ranked Law Firm seeks bioinformatics technical specialist, patent agent with experience. The candidate will be involved with a wide variety of work, including: patent preparation and prosecution, portfolio management, strategic analysis, client counseling, opinion work, and litigation support. Must have Degree…

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In response to your request for a modification to the atmosphere of break bulk cargo hold 17

Dear inhabitant 29413b, We appreciate your letter and especially the fact that you took the time to write to us about your feelings of anxiety regarding your surroundings. We are 100% committed to maintaining an environment in which everyone, including our more diverse members, is comfortable reaching out to share…

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Sickle Cell Disease Pipeline Drugs and Companies Insight Report (2022): Analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments

Sickle Cell Disease pipeline constitutes 40+ key companies continuously working towards developing 50+ Sickle Cell Disease treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. Sickle Cell Disease Overview Sickle Cell Disease is a group of inherited red blood cell disorders that…

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Doubt on annotation of ensembl ids in biomart using R

Doubt on annotation of ensembl ids in biomart using R 0 Hi All 🙂 I have a large list of unique ENSEMBL IDs (48,432) representing mouse genes, my goal only is to get attributes like gene name and ncbi id to build a dataset with expression data. However when using…

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Who are the leading innovators in DNA polymorphism detection for the pharmaceutical industry?

The pharmaceutical industry continues to be a hotbed of innovation, with activity driven by the evolution of new treatment paradigms, the gravity of unmet need, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence (AI). In the last three years alone, there have…

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First report of successful treatment of cervical lymph node metastasis with irreversible electroporation

doi: 10.1093/qjmed/hcac262. Online ahead of print. Affiliations Expand Affiliations 1 Department of Ultrasound Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China. 2 Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province, Hangzhou 310003, Zhejiang, China. Item in Clipboard Min Xu et al. QJM. 2022….

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Assistant Professor, Associate Professor, and Professor, Bio Sciences and Technology job with VELLORE INSTITUTE OF TECHNOLOGY

Job Description: Designations Available: Assistant Professor, Associate Professor, and Professor Desired Skillset: Applicants should preferably hold a Ph.D. in the relevant subject from reputed Institutions. Should have sufficient experience in Teaching, Industry & Research with reputed Institutions. Should have research papers published in International / National Journals….

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1 vacancy for JRF; Apply online

Guwahati, Nov 25: Indian Institute of Technology (IIT) Guwahati has released the official notification inviting interested and eligible candidates to apply for the post of Junior Research Fellow (JRF) in a DST-SERB sponsored project entitled, “Characterizing the functional role of the novel dopaminergic transmembrane protein p20MANI (Myelin-Associated Neurite Inhibitor)” in…

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New CRISPR gene-editing system can “drag-and-drop” DNA in bulk

A new technique has been added to the CRISPR gene-editing toolbox. Known as PASTE, the system uses virus enzymes to “drag-and-drop” large sections of DNA into a genome, which could help treat a range of genetic diseases. The CRISPR system originated in bacteria, which used it as a defense mechanism…

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Comment: Unable to convert "NULL" to either zero or NA

Fair enough, I just glanced over your screenshot, because that magrittr pipe is intimidatingly long, and you had already ascertained that *this is because some values in these columns are “NULL”. All the other times with other data frames the empty values are always “NA” and I can use na.rm=T…

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