Interpreting dbNSFP prediction scores
How should I interpret for example, SIFT score:
SIFT_pred = T;T;T;T;D;T SIFT_score = 0.138;0.138;0.138;0.138;0.042;0.157
From dbNSFP documentation, I understand the meaning of D and T
- D: Deleterious (sift<=0.05);
- T: tolerated (sift>0.05)
My question is: Why there are multiple values of both
score in this example?
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I guess I found the answer from dbNSFP readme file:
January 23, 2014: dbNSFP v2.2 is released. SIFT and FATHMM now have multiple scores corresponding to different
Ensembl ENSP ids and amino acid positions (aapos_SIFT and aapos_FATHMM). Accordingly, our companion search
program now supports SNP searches based on Ensembl ENSP ids and amino acid positions.
So each value corresponds to different Ensembl ENSP id and amino acid position (aapos_SIFT and aapos_FATHMM).
Read more here: Source link