Calculation of the GRM in GCTA

Calculation of the GRM in GCTA


Hi experts,

I am new to the field. I have some questions wrt the calculation of the GRM: by using the GCTA software:
Let’s say I have a population of genome data for N= 4800000, and the original genotype SNPs, and also the imputed SNPs. I want to calculate the GRM for my subsequent analysis, so my questions are:

  1. Should I use a subset of the SNPs, i.e., the original SNP calls from UKBB, or the full set of imputed genotype SNPs?
  2. Should I use the whole UKBB samples (N=480000+) or a subsample that I am actually interested in (N=20000+) is enough?
  3. Should I include the X and XY chromosomes or only use the first 22 autosomal chromosomes?

Thank you

Best regards




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