About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
The Bioinformatics Scientist (open level, from Postdoctoral Fellow to Research Assistant Professor) will work in a team environment in Andrea Bild’s lab studying tumor heterogeneity using whole genome sequencing and single cell sequencing approaches, among others. The project will focus on evolution of tumor resistance to therapy and is supported by our funded NIH Cancer Systems Biology Consortium ( csbconsortium.org/ ) program at City of Hope Comprehensive Cancer Center. This distinguished program provides exciting opportunities to engage with top scientists and cutting edge genomic research.
For this position, the scientist will lead efforts to analyze genomic data for detection of tumor subclone population evolution during therapy using WGS (for reference, please read: www.ncbi.nlm.nih.gov/pubmed/29093439 ), as well as subclonal phenotype and pathway activity using single cell sequencing data. S/he will manage the analysis and interpretation of genomics data from patient cohorts in order to understand why cancer progresses with resistant tumor clones that emerge during therapy. Signaling state changes in cancer and tumor associated normal cells during progression to resistance will be studied, as well as cell-cell interactions important in tumor growth. The successful candidate will also contribute to the development data workflow processes and pipelines. S/he will also have the opportunity to assist in training investigators and new users to use bioinformatics applications and databases.
Basic education, experience and skills required for consideration:
- PhD degree in bioinformatics or equivalent and experience with NGS sequencing data lead research projects.
- Demonstrated ability to solve biologically-relevant problems requiring novel applications of exploratory data analysis.
- Analyze data of high complexity by applying sound statistical and commonly accepted bioinformatics methods to -omics data with a collaborative project team.
- Excellent English written and oral communication skills.
- Excellence in scripting languages (python, perl) and with R.
- Knowledge of hardware including server.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
- Posting Date: Nov 6, 2020
- Job Field: Research
- Employee Status: Regular
- Shift: Day Job
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