Overview:
Bioinformatics ScientistOverall summary:The position will independently provide support services to satisfy the overall operational objectives of the National Institute on Environmental Health Sciences.Deliverables:Work products and documents related to designing experiments; analyze and interpret the biological data; prepare and present the results based on the scientific objectives; collaborate with and support scientists to analyze high throughput sequencing data. – Ad-HocWork products and documents related to integrating analysis of multi-data types generated internally and the use of publicly available datasets; write data analysis sections of manuscripts; prepare publication quality figures; deposit data to external repositories that meet publication requirements. – Ad-HocWork products and documents related to developing and maintaining custom software and pipelines; evaluate and utilize commercial and open source software as required by research projects. – Ad-HocWork products and documents related to establishing reproducible data analysis pipelines and standard operating procedures; provide detailed documentations for methodologies so they can be reproduced and applied to similar studies; provide ad hoc trainings and hands-on workshops on the use of bioinformatics tools. – Ad-HocWork products and documents related to participating in group meetings; present findings; – Ad-HocWork products and documents related to managing branch projects, epidemiologic study implementation, and data collection; documents related to procurement lifecycle, execution of contracts, and budgeting processes. – DailyWork products and documents related to preparing data summaries, manuscripts, professional presentations and patient educational materials; edit written documents; organize, attend and participate in multidisciplinary research team meetings and functions. – DailyWork details:Provides programming and troubleshooting support to the Federal Government in the dissemination of research data. Generate and optimize programs and scripts for the analysis of data; create programs and algorithms and develop computational infrastructure resources for organizing and parsing data from large and complex data Serve as bioinformatics expert and coordinate with teams of biologists to conduct experimental queries and or perform portions of studies using complex procedures and techniques common to modern bioinformaticsCoordinate building bioinformatics infrastructure to ensure easy and meaningful scientific analysis and interpretation of dataProvide broad-based programming and analytic support for a wide variety of bioinformatic and research projectsInstall, troubleshoot and run open-source and commercial scientific software on platformsPerforms computations on research data analysis. Perform computational analysis of, and interpret results 1Provide reports based on analysis of scientific dataPerform sequencing and alignment of raw data, and interpret new data using larger public access datasetsProvide interpretive analyses of data derived from different experimental platforms to generate biological meaningWrite custom programs and algorithms to support data analyses and discoveryWorks with staff on scientific programming and experimental designCollaborate with scientists to design, analyze, manage and interpret all types of data 3Design and execute computational experimentsWork with staff on planning of experiments, and data analysis for internal and collaborative projects; use bioinformatics expertise to advise and help bench scientists on experimental design and troubleshootingWork with staff to develop specifications for new analysis; design, test and implement solutionsMake recommendations to investigators about the correct computational tools for testing scientific hypotheses and reaching valid conclusionsRecords observations and report results at weekly laboratory meetings Maintain proper and detailed documentation of the analysis performed and report results at lab meetingsAttend scientific and programming meetings; take and compile comprehensive notes; organize and edit content of meeting reportsPrepare scientific reports and progress reports; assemble data to prepare tables, graphs and slides; conduct scientific and program related information searches and report resultsOrganize daily laboratory notebook on experiments; prepare weekly updates on on-going experiments and tasks; provide monthly progress notes on assigned projects; submit final progress reports and future directions on projectsOrganize laboratory notebook or computer database to record results of calculations Share results at lab meetingsProvides statistical support / analysis on research data. Devise novel methods of statistical analysis for collected dataUtilize and adapt existing bioinformatics techniques to check for trends and patterns in the dataWrite complex queries to multiple databasesPerform data processing and data analysis with existing computational and statistical methods 5Assist in evaluating and interpreting results for validity and scientific meaningProvides research / service goals in the context of the laboratory’s overall mission. Create novel programs and algorithms that facilitate discovery of knowledge in investigating large and complex data 4Develop and optimize programs and scripts that facilitate organization, integration and data mining of large data sets; integrate these models into a framework of best practices Participate in the design of new protocols involving computational methodsWork with staff on the development and maintenance of bioinformatics tools, scripts and pipelines for dataParticipate in research design with investigators for determining best practices pertaining to the bioinformatics analysis in new and ongoing projectsEvaluates new types of experimental approaches to protocols based on knowledge of scientific literature, available facilities and research needs. Research and review literature to retrieve targeted clinical or scientific information, including novel statistical methods, from publicly available resourcesCollaborate with staff to review current and historical procedures for the acquisition, quality control and management of dataAnalyze and evaluate data cleaning and harmonization needs in the using a variety of descriptive statistics and analytic methodsIdentify new tools and resources for reaching biologically meaningful conclusionsCollaborate with experimentalists and computational biologists to develop new computational tools to answer research questions of interestIndependently coordinates the training of personnel in the use of scientific software applications, statistical software applications and programmatic software applications. Provide training in and technical support including product updates and version control for programs, algorithms, archives, and pipelines generated during the course of this workInstruct staff in computational analysis of dataProvide ad hoc trainings and hands-on workshops on the use of bioinformatics toolsProvide training of students, new investigators, and other laboratory personnel in the use of techniques, procedures and equipment to complete the objectives of the laboratoryInitiates interdisciplinary collaborations with other research centers. Work with an interdisciplinary team to apply computational data analysis approaches to make biological discoveries 2Collaborate with group members in experiments associated with data collectionInteract with all levels of staff and communicate with outside collaborators in the US and abroad Work with staff, collaborate with outside researchers, and contribute to positive overall teamwork; teach Bioinformatics principles and methodologiesCollaborate with biologists, statisticians andor other bioinformaticians in the design of models summarizing explaining experimental data Deliver at least one presentation per year to audiences outside the Government. Attend group meetings; present findings; author publications resulting from projects Present analysis results at research conferences and meetingsPresent new research data in group settings, at meetings or seminars Present scientific and technical data at scientific conferences1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those rankedAdditional Qualifications:Education: Master’s ORPh.D. in Bioinformatics, Computational Biology or a related discipline, two years experienceCertifications & LicensesSkills (Ranked By Priority)Next gen sequencing data analysisMulti-omics AnalysisSingle Cell RNA-SequencingWork with large data setsPipeline developmentMicroarray data analysisData Quality ControlSequence AlignmentMachine LearningCore facility1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those rankedSoftwareRPythonPERLUnixJavaField of StudyMolecular BiologyGeneticsEnvironmental ScienceMathematics and Computer ScienceBenefits100% Medical Dental & Vision Coverage for EmployeesEducational Benefits for Career GrowthPaid Time Off (Including Holidays) Employee Referral Bonus Profit Sharing401K MatchingFlexible Spending Accounts:Healthcare (FSA)Parking Reimbursement Account (PRK)Dependent Care Assistant Program (DCAP)Transportation Reimbursement Account (TRN)The diversity of Axles employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate….. click apply for full job details
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