Polygenic Risk Score Plot

Polygenic Risk Score Plot

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I have a dataset of about 6000 people, Chromosome 21. I calculated PRS using plink and PRSice. The plot is shown above. I have two questions regarding this.

  1. R2 on the y-axis explains the phenotype variation, but I want another measure like AUC (area under the curve) for comparison with other tools.
  2. What these highlighted values (1,2,3 )are representing?

Polygenic Risk Score Plot


Risk


Plink


Polygenic


PRS


Score

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