Good or bad idea to annotate with newer genome build?

Good or bad idea to annotate with newer genome build?

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Hello Biostars Community,

If the probe sequences on a mouse methylation beadchip array is based on the (mm10) GRCm38 genome build, would it be a bad idea to annotate the probes with the latest genome build (mm39) GRCm39?

I am thinking yes it would be a bad idea, I just need some confirmation from peers, or maybe other helpful insight.

Thank you in advance!


array


methylation


beadchip


build


annotation

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