Using DNA sequencing data to quantify T cell fraction and therapy response

  • R.B. helped conceive the study, designed and conducted the bioinformatic analysis, and wrote the manuscript. K.L. curated the CPI1000+ cohort used in the study and provided considerable bioinformatic support on its analysis. T.B.K.W. provided considerable bioinformatic support on the analysis of the multi-sample pan-cancer cohort and helped conceive the study and write the manuscript. T.B.K.W. and E.L.L jointly curated the multi-sample pan-cancer cohort used in the study. R.R. and C.M.-R. provided considerable bioinformatic support in the transcriptomic analysis performed in the study, providing RNA-seq immune score metrics and assisting with the RNA-seq gene-expression analysis respectively. R.S., M.A.B., D.A.M. and C.T.H. jointly analysed histopathology-derived TIL estimates. M.J.-H. designed study protocols and helped to analyse patient clinical characteristics. C.S. helped provide study supervision and helped direct the avenues of bioinformatics analysis and also gave feedback on the manuscript. N.M. conceived and supervised the study and helped write the manuscript.

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