Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK
Robert Bentham, Carlos Martínez-Ruiz & Nicholas McGranahan
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK
Robert Bentham, Kevin Litchfield, Emilia L. Lim, Carlos Martínez-Ruiz, Crispin T. Hiley, David A. Moore, Mariam Jamal-Hanjani, Charles Swanton & Nicholas McGranahan
The Tumour Immunogenomics and Immunosurveillance Lab, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK
Kevin Litchfield
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK
Thomas B. K. Watkins, Emilia L. Lim, Rachel Rosenthal, Crispin T. Hiley, Maise Al Bakir & Charles Swanton
Department of Pathology, GZA-ZNA, Antwerp, Belgium
Roberto Salgado
Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia
Roberto Salgado
Department of Cellular Pathology, University College London Hospitals, London, UK
David A. Moore
Department of Medical Oncology, University College London Hospitals, London, UK
David A. Moore, Mariam Jamal-Hanjani & Charles Swanton
Cancer Metastasis Lab, University College London Cancer Institute, London, UK
Mariam Jamal-Hanjani
The Francis Crick Institute, London, UK
Nicolai J. Birkbak, Mickael Escudero, Aengus Stewart, Andrew Rowan, Jacki Goldman, Peter Van Loo, Richard Kevin Stone, Tamara Denner, Emma Nye, Sophia Ward, Stefan Boeing, Maria Greco, Jerome Nicod, Clare Puttick, Katey Enfield, Emma Colliver, Brittany Campbell, Alexander M. Frankell, Daniel Cook, Mihaela Angelova, Alastair Magness, Chris Bailey, Antonia Toncheva, Krijn Dijkstra, Judit Kisistok, Mateo Sokac, Oriol Pich, Jonas Demeulemeester, Elizabeth Larose Cadieux, Carla Castignani, Krupa Thakkar, Hongchang Fu, Takahiro Karasaki, Othman Al-Sawaf & Mark S. Hill
University College London Cancer Institute, London, UK
Takahiro Karasaki, Othman Al-Sawaf, Christopher Abbosh, Yin Wu, Selvaraju Veeriah, Robert E. Hynds, Andrew Georgiou, Mariana Werner Sunderland, James L. Reading, Sergio A. Quezada, Karl S. Peggs, Teresa Marafioti, John A. Hartley, Helen L. Lowe, Leah Ensell, Victoria Spanswick, Angeliki Karamani, Dhruva Biswas, Stephan Beck, Olga Chervova, Miljana Tanic, Ariana Huebner, Michelle Dietzen, James R. M. Black, Cristina Naceur-Lombardelli, Mita Afroza Akther, Haoran Zhai, Nnennaya Kanu, Simranpreet Summan, Francisco Gimeno-Valiente, Kezhong Chen, Elizabeth Manzano, Supreet Kaur Bola, Ehsan Ghorani, Marc Robert de Massy, Elena Hoxha, Emine Hatipoglu, Benny Chain, David R. Pearce, Javier Herrero & Simone Zaccaria
University College London Hospitals, London, UK
Mark S. Hill, David Lawrence, Martin Hayward, Nikolaos Panagiotopoulos, Robert George, Davide Patrini, Mary Falzon, Elaine Borg, Reena Khiroya, Asia Ahmed, Magali Taylor, Junaid Choudhary, Sam M. Janes, Martin Forster, Tanya Ahmad, Siow Ming Lee, Neal Navani, Dionysis Papadatos-Pastos, Marco Scarci, Pat Gorman, Elisa Bertoja, Robert C. M. Stephens, Emilie Martinoni Hoogenboom, James W. Holding, Steve Bandula, Ricky Thakrar, Radhi Anand, Kayalvizhi Selvaraju, James Wilson, Sonya Hessey, Paul Ashford, Mansi Shah & Marcos Vasquez Duran
Swansea Bay University Health Board, Swansea, UK
Jason Lester
Cardiff and Vale University Health Board, Cardiff, UK
Fiona Morgan, Malgorzata Kornaszewska, Richard Attanoos, Haydn Adams & Helen Davies
Cancer Research Centre, University of Leicester, Leicester, UK
Jacqui A. Shaw, Joan Riley, Lindsay Primrose & Dean Fennell
Leicester University Hospitals, Leicester, UK
Dean Fennell, Apostolos Nakas, Sridhar Rathinam, Rachel Plummer, Rebecca Boyles, Mohamad Tufail, Amrita Bajaj, Jan Brozik, Keng Ang & Mohammed Fiyaz Chowdhry
National Institute for Health Research Leicester Respiratory Biomedical Research Unit, Leicester, UK
William Monteiro & Hilary Marshall
University of Leicester, Leicester, UK
Alan Dawson, Sara Busacca, Domenic Marrone & Claire Smith
Barnet & Chase Farm Hospitals, Barnet, UK
Girija Anand & Sajid Khan
Aberdeen Royal Infirmary, Aberdeen, UK
Gillian Price, Mohammed Khalil, Keith Kerr, Shirley Richardson, Heather Cheyne, Joy Miller, Keith Buchan, Mahendran Chetty & Sylvie Dubois-Marshall
The Whittington Hospital NHS Trust, London, UK
Sara Lock & Kayleigh Gilbert
University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
Babu Naidu, Gerald Langman, Hollie Bancroft, Salma Kadiri, Gary Middleton, Madava Djearaman, Aya Osman, Helen Shackleford & Akshay Patel
Manchester Cancer Research Centre Biobank, Manchester, UK
Angela Leek, Nicola Totten, Jack Davies Hodgkinson, Jane Rogan, Katrina Moore & Rachael Waddington
Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK
Raffaele Califano, Rajesh Shah, Piotr Krysiak, Kendadai Rammohan, Eustace Fontaine, Richard Booton, Matthew Evison, Stuart Moss, Juliette Novasio, Leena Joseph, Paul Bishop, Anshuman Chaturvedi, Helen Doran, Felice Granato, Vijay Joshi, Elaine Smith, Angeles Montero & Philip Crosbie
Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK
Philip Crosbie
Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Manchester, UK
Philip Crosbie, Fiona Blackhall, Lynsey Priest, Matthew G. Krebs, Caroline Dive, Dominic G. Rothwell, Alastair Kerr & Elaine Kilgour
Christie NHS Foundation Trust, Manchester, United Kingdom
Fiona Blackhall, Lynsey Priest, Matthew G. Krebs, Katie Baker, Mathew Carter, Colin R. Lindsay & Fabio Gomes
Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK
Caroline Dive, Dominic G. Rothwell, Alastair Kerr, Elaine Kilgour, Jonathan Tugwood, Jackie Pierce & Alexandra Clipson
Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Roland Schwarz & Matthew Huska
German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany
Roland Schwarz
Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
Tom L. Kaufmann
BIFOLD, Berlin Institute for the Foundations of Learning and Data, Berlin, Germany
Tom L. Kaufmann
Danish Cancer Society Research Center, Copenhagen, Denmark
Zoltan Szallasi
Department of Physics of Complex Systems, ELTE Eötvös Loránd University, Budapest, Hungary
Istvan Csabai & Miklos Diossy
Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA
Hugo Aerts
Radiology and Nuclear Medicine, CARIM & GROW, Maastricht University, Maastricht, The Netherlands
Hugo Aerts & Charles Fekete
Department of Medical Physics and Bioengineering, University College London Cancer Institute, London, UK
Gary Royle & Catarina Veiga
Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland
Marcin Skrzypski
Independent Cancer Patients Voice, London, UK
Mairead MacKenzie & Maggie Wilcox
Cancer Research UK and UCL Cancer Trials Centre, London, UK
Allan Hackshaw, Yenting Ngai, Abigail Sharp, Cristina Rodrigues, Oliver Pressey, Sean Smith, Nicole Gower, Harjot Kaur Dhanda, Kitty Chan & Sonal Chakraborty
University Hospital Southampton NHS Foundation Trust, Southampton, UK
Christian Ottensmeier, Serena Chee, Benjamin Johnson, Aiman Alzetani, Judith Cave, Lydia Scarlett & Emily Shaw
Royal Brompton and Harefield NHS Foundation Trust, London, UK
Eric Lim, Paulo De Sousa, Simon Jordan, Alexandra Rice, Hilgardt Raubenheimer, Harshil Bhayani, Morag Hamilton, Lyn Ambrose, Anand Devaraj, Hema Chavan, Sofina Begum, Silviu I. Buderi, Daniel Kaniu, Mpho Malima, Sarah Booth, Andrew G. Nicholson, Nadia Fernandes, Christopher Deeley, Pratibha Shah & Chiara Proli
Barts Health NHS Trust, London, UK
Kelvin Lau, Michael Sheaff, Peter Schmid, Louise Lim & John Conibear
Ashford and St Peter’s Hospitals NHS Foundation Trust, Chertsey, UK
Madeleine Hewish
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
Sarah Danson, Jonathan Bury, John Edwards, Jennifer Hill, Sue Matthews, Yota Kitsanta, Jagan Rao, Sara Tenconi, Laura Socci, Kim Suvarna, Faith Kibutu, Patricia Fisher, Robin Young, Joann Barker, Fiona Taylor & Kirsty Lloyd
Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK
Michael Shackcloth & Julius Asante-Siaw
Royal Liverpool University Hospital, Liverpool, UK
John Gosney
The Princess Alexandra Hospital NHS Trust, Harlow, UK
Teresa Light, Tracey Horey, Peter Russell & Dionysis Papadatos-Pastos
NHS Greater Glasgow and Clyde, Glasgow, UK
Kevin G. Blyth, Craig Dick & Andrew Kidd
Golden Jubilee National Hospital, Clydebank, UK
Alan Kirk, Mo Asif, John Butler, Rocco Bilancia, Nikos Kostoulas & Mathew Thomas
Achilles Therapeutics UK Limited, London, UK
Gareth A. Wilson
R.B. helped conceive the study, designed and conducted the bioinformatic analysis, and wrote the manuscript. K.L. curated the CPI1000+ cohort used in the study and provided considerable bioinformatic support on its analysis. T.B.K.W. provided considerable bioinformatic support on the analysis of the multi-sample pan-cancer cohort and helped conceive the study and write the manuscript. T.B.K.W. and E.L.L jointly curated the multi-sample pan-cancer cohort used in the study. R.R. and C.M.-R. provided considerable bioinformatic support in the transcriptomic analysis performed in the study, providing RNA-seq immune score metrics and assisting with the RNA-seq gene-expression analysis respectively. R.S., M.A.B., D.A.M. and C.T.H. jointly analysed histopathology-derived TIL estimates. M.J.-H. designed study protocols and helped to analyse patient clinical characteristics. C.S. helped provide study supervision and helped direct the avenues of bioinformatics analysis and also gave feedback on the manuscript. N.M. conceived and supervised the study and helped write the manuscript.
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