Korean red ginseng reduces ageing-related issues in postmenopausal women

Although no exact mechanism has been identified for the ageing process in women after menopause, several epidemiological studies have shown that there are many diseases related to ageing in postmenopausal women, such as type 2 diabetes and cardiovascular disease​, both of which are closely linked to oxidative stress and chronic low-grade inflammation.

Both mitochondria DNA (mtDNA) mutations and decreases in mtDNA copy number (a measure of the number of mitochondrial genomes per cell) interrupt mitochondrial function, which may lead to ageing. In addition, free radicals accumulate in macromolecules, such as fat, DNA, and protein, and oxidative stress leads to cellular senescence, which induces the expression of various inflammatory cytokines and proteins, which in turn promote ageing​.

Korean red ginseng (KRG), aka Panax ginseng Meyer, has antioxidant properties​ which can improve immune health, fatigue symptoms, blood circulation, and memory function.

The current 8-week, randomised, double-blind, placebo-controlled, clinical trial aimed to investigate the effect of KRG primarily on biological ageing and antioxidant capacity, and how it affects clinical fatigue symptoms.

The mtDNA copy number of lymphocytes was used to determine biological ageing, TAS was measured to evaluate antioxidant capability, and a Fatigue Severity Scale (FSS) questionnaire was used as an indicator of clinical symptoms for fatigue. 

This is the first randomised, double-blind, placebo-controlled study to investigate the comprehensive efficacy of KRG administration on biological ageing, antioxidant activity, and clinical symptoms in Korean postmenopausal women. 

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