How to estimate polygenic risk score (PRSs) using the scoring files from PGSCatalog for one individual?

How to estimate polygenic risk score (PRSs) using the scoring files from PGSCatalog for one individual?

2

Hi all,

I have an annotated vcf file for one individual which I want to estimate his polygenic risk score (PRS) for a certain trait, using the scoring files from the PGSCatalog. The scoring file contains the SNP ID, reference and alternative allele, and weights. How can I estimate the PRS using the scoring file without using the classical approach of having GWAS summary data, target data, etc…?

Thank you very much for your consideration.


prs


genome


snp

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