How to estimate polygenic risk score (PRSs) using the scoring files from PGSCatalog for one individual?
I have an annotated vcf file for one individual which I want to estimate his polygenic risk score (PRS) for a certain trait, using the scoring files from the PGSCatalog. The scoring file contains the SNP ID, reference and alternative allele, and weights. How can I estimate the PRS using the scoring file without using the classical approach of having GWAS summary data, target data, etc…?
Thank you very much for your consideration.
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