The Role of Mitochondrial Genes in Neurodegenerative Disorders

This article was originally published here

Curr Neuropharmacol. 2021 Sep 8. doi: 10.2174/1570159X19666210908163839. Online ahead of print.


Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and Stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains unclear in depth.

PMID:34503413 | DOI:10.2174/1570159X19666210908163839

Read more here: Source link