How do I determine p-value and fold change for TMM normalized data?
I have a TMM normalized data for cancer vs no cancer treatment. This data, however, does not contain p-value or fold change. I want to generate plots such as heatmaps and volcano plots, but I cann’t do it without their p-values and fold changes. I also do not have the raw counts. Is there a way to calculate p-value and fold change for this normalized data. Any help is greatly appreciated.
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