PhD position (Ageing & Disease, Bioinformatics & Computational Biology): Reprogramming of immune and vascular cells in disease (m/f/d), Mainz – Institute of Molecular Biology gGmbH – Biology & Life Sciences

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) on Gene Regulation, Epigenetics & Genome Stability is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities

In the field of “Aging and Disease” and \”Bioinformatics & Computational Biology\”, the IPP research group of Prof. Dr Wolfram Ruf offers the following PhD project:

The hematopoietic system is maintained by a constant replenishment of blood cells from stem and progenitor populations in the bone marrow. Megakaryocytes are a key cell type in the bone marrow that generate blood platelets as well as maintain hematopoietic stem cells and the output of lineage committed progenitors. Platelet transcriptomics is an approach to gain insight into the differentiation and function of megakaryocytes in inflammatory diseases and aging. The cross species comparison of transcriptomes from genetically modified mice subjected to diseases models with human samples can yield new mechanistic insights in diseases processes that involve the hematopoietic system and its regulation by coagulation proteases and their cognate G protein-coupled receptors.

PhD Project: Platelet transcriptomics: from mice to man

This is a project focused on bioinformatics with the goal to analyze available large data sets and perform comparison with data sets available publically.

Qualification profile

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

  • Master or equivalent
  • Interactive personality & good command of English
  • 2 letters of reference

We offer

  • Exciting, interdisciplinary projects in a fully international environment, with English as our working language
  • Advanced training in scientific techniques and professional skills
  • Access to our state-of-the-art Core Facilities and their technical expertise
  • Fully funded positions with financing until the completion of your thesis
  • A lively community of more than 150 PhD students from 40 different countries

Send application to

For more details on the projects offered and how to apply via our online form, please visit

The deadline for registration is 26 November 2021. Interviews will take place (potentially online) 17-19 January 2022.
Starting date: 1 March 2022 – 1 September 2022

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