How can we compare EdgeR to limma-voom?

How can we compare EdgeR to limma-voom?


Hi all,

I did all my RNA-seq analysis for 500 patients with the EdgeR workflow as described in the manual.
Now I read an article (F1000 research) where they state that EdgeR is mostly preferred in low-count situations, where limma-voom is recommended in large scale datasets.
I thought using EdgeR was fine for my experiment, but this article has me worried.
Would limma-voom be preferred in my case or is EdgeR equally fine? Maybe good to know, I have no problems with computational times when using EdgeR.

Many thanks in advance!




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