Matching my VCF genome with ClinVar

Matching my VCF genome with ClinVar

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Hello,

I’m desperately trying to match my genome with ClinVar, I’ve been on it for several hours but nothing is working

Now I have found this software which looks good github.com/brentp/slivar

But I don’t understand anything about the parameters, I have my genome in vcf.gz and the ClinVar database in the same format aligned with the GRCh38, I would like to find variants referenced as “pathogenic” or “likely pathogenic”

Can you help me ?

Thank you.


software

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