Roche hiring Head of Pharma Services Bioinformatics, Molecular Lab Applications in Pleasanton, California, United States

As the Head of Services and Pharma Collaborations Bioinformatics, Molecular Lab Applications you will play a key role in growing Roche’s services business that supports key strategic initiatives in Oncology, Genetics, and Women’s Health. You will implement and manage bioinformatics operations for assays in Roche’s San Jose CLIA laboratory, and other external services labs. The assays include the Harmony NIPT assay and a growing suite of Oncology LDT’s used by pharma partners for their clinical trials. As a key leader in the pharma services program, you will collaborate closely with partner functions to shape and execute on pharma collaborations critical to Roche’s molecular lab IVD strategy. 

Responsibilities

• Work within multidisciplinary project teams to implement Bioinformatics pipelines for Roche’s CLIA services and pharma collaborations. Technologies supported include microarray and next generation sequencing

• Serve as Bioinformatics subject matter expert for scientific, technical and operational aspects of CLIA services and pharma collaborations

• Oversee Bioinformatics assay development and analytical validation including study design, data processing, analysis, presentation, and documentation of results for all services assays

• Accountable for Bioinformatics pipeline development and implementation of data management lifecycle

• Partner with CLIA lab colleagues to meet sample quality and turn around time goals

• Analyze data to troubleshoot and resolve operational matters in CLIA laboratory. Build data analysis tools to automate troubleshooting and real time lab quality monitoring

• Partner with commercial and assay development colleagues to align Bioinformatics strategy with long term Oncology & Genetics lifecycle goals  

• Complement existing commercial and open source methods with internally developed methods as needed to meet project objectives

• Provide requirements to software and wet lab development teams to support program goals

• Serve as technical consultant to external partner labs 

• Drive continuous process improvement to iteratively refine product development processes, product quality, and lab operations

• Serve as Computational Biology representative on regulatory submissions or interactions with regulatory bodies 

• Mentor a team of bioinformatics data scientists and engineers; provide staff with coaching, opportunities to develop skills, provide constructive and timely feedback on performance and progress toward goals and expectations

• Serve as Bioinformatics representative on the CLIA site leadership team

Qualifications

• Ph.D. in Bioinformatics, Computer Science, Statistics or other quantitative field with 4 years professional experience working with Next Generation Sequencing (NGS) or microarray on clinical diagnostics, or equivalent combination of education and experience

• 2+ years of management experience mentoring Bioinformatics scientists, data scientists and/or statisticians

• Deep expertise in statistical analysis, Bioinformatics algorithms (variant calling and QC methods), pipeline engineering, and assay development

• Demonstrated experience working in multi-disciplinary teams delivering highly complex Bioinformatics pipelines for LDT or IVD products 

• Thorough scientific understanding of cancer and women’s health diagnostics with strong ability to translate knowledge to innovative products

• Ability to create and present plans, roadmaps, and data analysis results in a clear and concise manner to audiences from different professional backgrounds

• Demonstrated ability to establish, communicate, and execute against scientific strategy for complex operations

• Prior experience managing collaborations with external partners

• Strong data analysis skills using R, Python, or other modern data analysis language

• Committed to scientific rigor and history of leading innovative science teams

• Champion continuous process improvement to iteratively refine product development processes, product quality, and lab operations

• Thrive in complex organization settings. Able to influence others in a matrixed environment. Strong interpersonal, teamwork, and organizational skills with ability to incorporate feedback in a professional manner

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.If you have a disability and need an accommodation in connection with the on-line application process, please email us at US.Accommodation@roche.com .

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.