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KEGG ENZYME: 2.2.1.3

 September 24, 2021

Entry
EC 2.2.1.3                  Enzyme                                 
Name

formaldehyde transketolase;
dihydroxyacetone synthase

Class

Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases

Sysname

D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase

Reaction(IUBMB)
D-xylulose 5-phosphate + formaldehyde = D-glyceraldehyde 3-phosphate + glycerone [RN:R01440]
Reaction(KEGG) Substrate
D-xylulose 5-phosphate [CPD:C00231];
formaldehyde [CPD:C00067]
Product
D-glyceraldehyde 3-phosphate [CPD:C00118];
glycerone [CPD:C00184]
Comment
A thiamine-diphosphate protein. Not identical with EC 2.2.1.1 transketolase. Also converts hydroxypyruvate and formaldehyde into glycerone and CO2.
History

EC 2.2.1.3 created 1984

Pathway
ec01120   Microbial metabolism in diverse environments
Orthology
K17100   dihydroxyacetone synthase
Genes  » show all
Reference   Authors

Bystrykh LV, Sokolov AP, Trotsenko IuA.

  Title

[Separation of transketolase and dihydroxyacetone synthase from methylotrophic yeasts]

  Journal

Dokl Akad Nauk SSSR 258:499-501 (1981)

Reference   Authors

Kato N, Higuchi T, Sakazawa C, Nishizawa T, Tani Y, Yamada H

  Title

Purification and properties of a transketolase responsible for formaldehyde fixation in a methanol-utilizing yeast, candida boidinii (Kloeckera sp.) No. 2201.

  Journal Reference   Authors

Waites MJ, Quayle JR.

  Title

The interrelation transketolase and dihydroxyacetone synthase activities in the methylotrophic yeast Candida boidinii.

  Journal Other DBs
ExplorEnz – The Enzyme Database:  2.2.1.3
IUBMB Enzyme Nomenclature:  2.2.1.3
ExPASy – ENZYME nomenclature database:  2.2.1.3
BRENDA, the Enzyme Database:  2.2.1.3

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