Bioconductor – LineagePulse

DOI: 10.18129/B9.bioc.LineagePulse  

 

This package is for version 3.7 of Bioconductor;
for the stable, up-to-date release version, see
LineagePulse.

Differential expression analysis and model fitting for single-cell RNA-seq data

Bioconductor version: 3.7

LineagePulse is a differential expression and expression model fitting package tailored to single-cell RNA-seq data (scRNA-seq). LineagePulse accounts for batch effects, drop-out and variable sequencing depth. One can use LineagePulse to perform longitudinal differential expression analysis across pseudotime as a continuous coordinate or between discrete groups of cells (e.g. pre-defined clusters or experimental conditions). Expression model fits can be directly extracted from LineagePulse.

Author: David S Fischer [aut, cre], Fabian Theis [ctb], Nir Yosef [ctb]

Maintainer: David S Fischer <david.fischer at helmholtz-muenchen.de>

Citation (from within R,
enter citation("LineagePulse")):

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("LineagePulse")

Documentation

To view documentation for the version of this package installed
in your system, start R and enter:

browseVignettes("LineagePulse")

 

Details

biocViews CellBasedAssays, CellBiology, DifferentialExpression, GeneExpression, Sequencing, SingleCell, Software, StatisticalMethod, TimeCourse
Version 1.0.0
License Artistic-2.0
Depends
Imports BiocParallel, circlize, compiler, ComplexHeatmap, ggplot2, gplots, grDevices, grid, knitr, Matrix, methods, RColorBrewer, SingleCellExperiment, splines, stats, SummarizedExperiment, utils
LinkingTo
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SystemRequirements
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URL
BugReports github.com/YosefLab/LineagePulse/issues
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