Blood Derived Normal RNA_seq samples TCGA

Blood Derived Normal RNA_seq samples TCGA


Hi, does anyone know if there are any Blood Derived Normal samples with RNAseq data in any of the TCGA databases?
I want to compare exon quantification between normal and cancer samples but I can’t find any normal blood samples.





There are blood derived normal samples for many solid tumors (e.g. breast cancer). Edit: Not for RNA-seq though.

If you want blood derived normal samples for blood cancers such as lymphoma/leukemia, you won’t be able to find any.

I don’t think there are any. In order to double check, you could do this:
This table show the codes for sample types; so all you need to know to figure out what kind of sample you are looking at is the last two digit barcode.
You could go to Xena, look at the pages corresponding to the cancer types of your interest and check if there are any samples with the corresponding barcode.
I didn’t find any but what if I’m missing something

As @khorms mentioned, there doesn’t seem to be any RNA-Seq data for TCGA blood-derived normal samples available on TCGA. You can quickly check this by using the filters to explore the repository page on GDC. I’ve also checked legacy repository, but still couldn’t find anything. You can email GDC support for a confident answer if you’d like to double check.

Also, is there a reason as to why you want to use blood-derived normal samples (not familiar with exon quantification pipelines) instead of solid tissue normal samples? There’s probably differences in expression levels between a normal tissue and a blood sample. To my understanding, this is why researchers utilize matched normal tissue samples to examine normal vs. cancer for their study.

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