(ProNewsReport Editorial):- New York City, New York Sep 26, 2021 (Issuewire.com) – Oligonucleotide synthesis, the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure, plays an important role in creating biomolecules for biological, medical, and clinical applications. Up to August 2021, more than 14 oligonucleotide drugs have been approved by FDA (the United States Food and Drug Administration) for the treatment of liver, spinal cord, and skeletal muscle-based disorders, while for oncology treatment, more than 200 are in various phases of clinical trials, which shows the great potential of oligonucleotides.
Supported by in-house scientists and first-in-class technological platforms, Creative Biolabs now announces custom oligonucleotide synthesis services with a dedication to advancing customers’ programs with a diversity of research purposes and applications. The package of related services includes but is not limited to mRNA synthesis, miRNA synthesis, siRNA synthesis, RNA longmer synthesis, degenerated oligo synthesis, plate oligonucleotide synthesis, and antisense oligonucleotide synthesis.
Custom mRNA synthesis is one of the featured services at Creative Biolabs. Creative Biolabs has a wealth of skills providing customers with comprehensive mRNA synthesis at varying phases of their projects, covering synthesis of the gene, plasmid cloning and purification, full DNA sequencing documentation, PCR amplification of insert and PCR products purification, mRNA synthesis by in vitro transcription and purification and quality control. The scientist team can produce research-grade or GMP-grade mRNAs and customize synthesis at milligram to multigram scales.
For the siRNA synthesis service, rich experience has been accumulated in creating a custom siRNA using online design tools and extensive synthesis options for specific applications. Creative Biolabs guarantees to provide various synthesis, purification, modifications, and labelings options for special siRNA, which can be in single-stranded or duplex-stranded formats, with genome-wide coverage against human, mouse, and other species.
Antisense oligonucleotides synthesis is also available and can be performed using DNA, 2′-O-Methyl RNA, RNA, or constrained nucleotide bases with either phosphorothioate or unmodified internucleotide bonds. Besides, featured antisense oligonucleotides (ASOs) products with comprehensive plasmid backbones and gene modifications against certain human diseases at Creative Biolabs can be a boost to research on safe and efficacious drug candidates.
Further information can be found at www.creative-biolabs.com/gene-therapy/.
About Creative Biolabs
With years of experience in providing one-stop preclinical development services, Creative Biolabs has built a team of expertise of solid knowledge of gene therapy and is fully competent in providing services for worldwide clients. The services include but are not limited to delivery vehicles development, gene editing for gene therapy, RNAi therapy development, safety and toxicology analysis, potency tests, and solutions of specific gene therapy development for diseases.
Read more here: Source link