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KEGG ENZYME: 2.7.1.90

 September 28, 2021

Entry
EC 2.7.1.90                 Enzyme                                 
Name

diphosphate—fructose-6-phosphate 1-phosphotransferase;
6-phosphofructokinase (pyrophosphate);
pyrophosphate-fructose 6-phosphate 1-phosphotransferase;
inorganic pyrophosphate-dependent phosphofructokinase;
inorganic pyrophosphate-phosphofructokinase;
pyrophosphate-dependent phosphofructo-1-kinase;
pyrophosphate-fructose 6-phosphate phosphotransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

diphosphate:D-fructose-6-phosphate 1-phosphotransferase

Reaction(IUBMB)
diphosphate + D-fructose 6-phosphate = phosphate + D-fructose 1,6-bisphosphate [RN:R00764]
Reaction(KEGG) Substrate
diphosphate [CPD:C00013];
D-fructose 6-phosphate [CPD:C00085]
Product
phosphate [CPD:C00009];
D-fructose 1,6-bisphosphate [CPD:C00354]
Comment
The enzyme catalyses a similar reaction to EC 2.7.1.11, 6-phosphofructokinase, but utilizes diphosphate instead of ATP as the the phosphate donor. It has been described in higher plants, primitive eukaryotes, bacteria, and archaea.
History

EC 2.7.1.90 created 1976

Pathway
ec00010   Glycolysis / Gluconeogenesis
ec00030   Pentose phosphate pathway
ec00051   Fructose and mannose metabolism
ec01110   Biosynthesis of secondary metabolites
ec01120   Microbial metabolism in diverse environments
Orthology
K00895   diphosphate-dependent phosphofructokinase
K21071   ATP-dependent phosphofructokinase / diphosphate-dependent phosphofructokinase
Genes  » show all
Reference   Authors

Reeves RE, Serrano R, South DJ.

  Title

6-phosphofructokinase (pyrophosphate). Properties of the enzyme from Entamoeba histolytica and its reaction mechanism.

  Journal

J Biol Chem 251:2958-62 (1976)

  Sequence Reference   Authors

Reeves RE, South DJ, Blytt HJ, Warren LG.

  Title

Pyrophosphate:D-fructose 6-phosphate 1-phosphotransferase. A new enzyme with the glycolytic function of 6-phosphofructokinase.

  Journal

J Biol Chem 249:7737-41 (1974)

  Sequence Reference   Authors

Carlisle SM, Blakeley SD, Hemmingsen SM, Trevanion SJ, Hiyoshi T, Kruger NJ, Dennis DT

  Title

Pyrophosphate-dependent phosphofructokinase. Conservation of protein sequence between the alpha- and beta-subunits and with the ATP-dependent phosphofructokinase.

  Journal

J Biol Chem 265:18366-71 (1990)

  Sequence Reference   Authors

Ladror US, Gollapudi L, Tripathi RL, Latshaw SP, Kemp RG

  Title

Cloning, sequencing, and expression of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii.

  Journal

J Biol Chem 266:16550-5 (1991)

  Sequence Reference   Authors

Siebers B, Klenk HP, Hensel R

  Title

PPi-dependent phosphofructokinase from Thermoproteus tenax, an archaeal descendant of an ancient line in phosphofructokinase evolution.

  Journal   Sequence Other DBs
ExplorEnz – The Enzyme Database:  2.7.1.90
ExPASy – ENZYME nomenclature database:  2.7.1.90

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