KEGG ENZYME: 6.3.2.6

Entry
EC 6.3.2.6                  Enzyme                                 
Name

phosphoribosylaminoimidazolesuccinocarboxamide synthase;
phosphoribosylaminoimidazole-succinocarboxamide synthetase;
PurC;
SAICAR synthetase;
4-(N-succinocarboxamide)-5-aminoimidazole synthetase;
4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase;
SAICARs;
phosphoribosylaminoimidazolesuccinocarboxamide synthetase;
5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase

Class

Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)

Sysname

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)

Reaction(IUBMB)
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate [RN:R04591]
Reaction(KEGG) Substrate
ATP [CPD:C00002];
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [CPD:C04751];
L-aspartate [CPD:C00049]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate [CPD:C04823]
Comment

Forms part of the purine biosynthesis pathway.

History

EC 6.3.2.6 created 1961, modified 2000, modified 2006

Pathway
ec01110   Biosynthesis of secondary metabolites
Orthology
K01587   phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
K01923   phosphoribosylaminoimidazole-succinocarboxamide synthase
K13713   fusion protein PurCD
Genes  » show all
Reference   Authors

LUKENS LN, BUCHANAN JM.

  Title

Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5′-phosphate from 5-amino-1-ribosylimidazole 5′-phosphate and carbon dioxide.

  Journal

J Biol Chem 234:1799-805 (1959)

Reference   Authors

Parker J.

  Title

Identification of the purC gene product of Escherichia coli.

  Journal Reference   Authors

Ebbole DJ, Zalkin H.

  Title

Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis.

  Journal

J Biol Chem 262:8274-87 (1987)

  Sequence Reference   Authors

Chen ZD, Dixon JE, Zalkin H.

  Title

Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants.

  Journal   Sequence Reference   Authors

O’Donnell AF, Tiong S, Nash D, Clark DV

  Title

The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway.

  Journal

Genetics 154:1239-53 (2000)

  Sequence Reference   Authors

Nelson SW, Binkowski DJ, Honzatko RB, Fromm HJ.

  Title

Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.

  Journal Other DBs
ExplorEnz – The Enzyme Database:  6.3.2.6
IUBMB Enzyme Nomenclature:  6.3.2.6
ExPASy – ENZYME nomenclature database:  6.3.2.6
BRENDA, the Enzyme Database:  6.3.2.6

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