Sequence similarity networks with python

How to build sequence similarity networks within python? Pythoscape seems no longer available and biopython pairwise does not seem the most suitable for thousands of sequences. Any ideas? Thank you

There are lots of algorithms out there for aligning sequences, both pairwise alignments and multiple sequence alignments. These calculations are relatively slow, and you generally wouldn’t want to write such an algorithm in Python. Instead, you can use Biopython to invoke a command line tool on your behalf.

From Biopython-readthedocks.