Calculation of tRNA abundances from different cell types

Calculation of tRNA abundances from different cell types

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Dear all,

My research group had completed an analysis on tRNA levels before I joined to study.

The aim was to compare tRNA abundances of healthy and diseased groups and they have raw data from bulk RNA sequencing. However, bulk RNA-seq results from healthy group are from endothelial cells; whereas bulk RNA-seq results from diseased group are from peripheral blood. They calculated tRNA abundances based on different cell types.

I disagree about the reliability of the comparison of such results, because difference in cell types can affect tRNA abundances, irrelevant from health state.

Do you think such comparison is valid?

I would be grateful if you could share your ideas.

Thanks a lot,


abundance


Transcript


tRNA


bulk


RNA-Seq

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