Replacing BAM with CRAM Files

Replacing BAM with CRAM Files


I’m starting to explore mapped sequence data formats. Specifically the possibility of replacing bam files with cram files, as bam and/or ubam files are generally quite heavy. Thus can affect transfer and computational times used in my linux systems.

However I wanted to know if other users have any experience with similar situations where the cram files will closely resemble the original bam/ubam files. In other words, can cram files be used as alternative to bam/ubam files in the input analysis.




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