This video lecture explains
1. What is epigenetics?
2. What are different factors and processes affecting epigenetics?
3. What is DNA methylation?
4. How DNA methylation regulates gene expression?
5. What is bisulfite sequencing?
6. What are histones?
7. What is histone modification?
8. How histone modification regulates gene expression?
9. What are the end points of epigenetics?
Biology Lectures is a research organization with the mission of providing a free, world-class education for anyone, anywhere. We offer quizzes, questions,…
This course is a part of a series of bioinformatics modules designed to introduce biologists to analysis of various omics data types. Learn more: edu.t-bio.info/course/epigenetics-1/
Epigenetics refers to mechanisms of gene expression regulation that do not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation.
Epigenetic regulations play an important role in a variety of human…
There are many techniques for analyzing changes in DNA methylation. The method used depends on factors including but not limited to the availability of the DNA, total number of targets being analyzed and the desired specificity. Bisulfite modification of DNA is the foundation for the majority of assays geared toward analyzing changes in DNA methylation patterns. Bisulfite modification converts non-methylated cytosines to uracils, which are then converted to thymines during DNA amplification by PCR. Methylated cytosines are protected from…
You know all about how DNA bases can code for an organism’s traits, but did you know there’s more influencing phenotype than just the bases? Explore epigenetics with the Amoeba Sisters by learning about a few types of epigenetic marks and some examples of them in action.
2:14 Epigenetic Marks
4:13 Studies Involving Rodents & Epigenetics
5:51 Points about Inheritance and Factors Involving Inheritance
7:01 Why study Epigentics?
7:51 Epigentic Therapy
Clark, Mary Ann, Matthew Douglas,…
todays topic will be: Bisulfite Sequencing, which is a method for the detection of DNA Methylation.
Hope you enjoy it.
Introduction to epigenetic modifications: acetylation and lysine methylation of histone proteins.
Made by Drs Adam and Katherine West, University of Glasgow, UK
Precision Medicine Lecture Series
Speaker: Timothy Bestor, PhD
Sponsored by: The Irving Institute for Clinical and Translational Research
In this video, you will learn what epigenetic modifications are and how to profile epigenetic modifications using next-generation sequencing approaches. If you want more information on epigenomic methodologies, please visit our website at cd-genomics.com.
DNA methylation is a process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence.
CpG Islands : youtube.com/watch?v=2964vuECi-A
Epigenetics is the study of changes in gene function that are heritable and that are not attributed to alterations of the DNA sequence. Epigenetics can cause changes in gene expression but that are not changes in the DNA sequence. These mechanisms include DNA methylation, histone modification, and non-coding RNA such as micro RNAs and the effect of non-coding repeating regions in the DNA code.
#DNAmethylation #Epigenetics #Genetics
Studies show that supplementation with methyl donors such as folate, choline and vitamin B12 may influence DNA methylation and may have a beneficial effect on CVD risk. In this animation we see that epigenetic information provides instructions on how, where and when the genetic information should be used.
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This module discusses the ways that we study histone modifications in epigenomes, primarily through chromatin immunoprecipitation (ChIP) and ChIP-Seq analysis. At the beginning of this course module you will be introduced to the basics of ChIP and ChIP-Seq analysis followed by a more practical section on how to prepare for ChIP and how to analyze ChIP-Seq results. Finally, you’ll participate in a hands on ChIP-Seq analysis activity and have the opportunity to complete your own research project, if you choose. Learn about it with hands-on…
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