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Postdoc fellow – CRISPR screens to study genome integrity in stem cells and leukemia
A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases and leukemias. The laboratory of Dr. Wei Tong studies cytokine receptor signaling in replication stress, DNA repair, ribosome biogenesis, and ubiquitin signaling in hematopoietic stem cells, bone marrow failure, and leukemia.
Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation, and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to leukemia. Genome integrity plays a critical role in blood development and the prevention of leukemia and aging.
This postdoctoral fellow position will focus on studying the mechanisms that safeguard the genome during DNA replication and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. CRISPR screens with our expert collaborators will delineate a new understanding of stem cell fitness upon replication stress and point to potentially druggable pathways for intervention in treating diseases with stem cell dysregulation.
Recent publications in Dr. Tong lab include Cell Stem Cell, July, 2021; Blood Jun 2021; Nature communications 9(1): 3915, Sep 2018; Genes & development 31(10): 1007-1023, May 2017; Blood 133(14): 1560-1571, Apr 2019. You can find more of our recent publication and laboratory information on the below website.
www.med.upenn.edu/apps/faculty/index.php/g275/p8146029
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Candidates should have a PhD or equivalent degree and experience investigating biochemistry, cell biology, molecular biology, and mouse models.
Highly motivated candidates with publication records are encouraged to apply. Please email or send applications with a brief statement of research experience and interest, CV, and contact information for at least two references to:
Wei Tong, PhD
Professor and CHCA Chair in Pediatrics,
Children’s Hospital of Philadelphia,
University of Pennsylvania School of Medicine,
Co-Director, Hematopoietic Stem Cell program,
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Institute for Regenerative Medicine at UPENN
Abramson Bldg. 310D,
3615 Civic Center Blvd.,
Philadelphia, PA 19104
Tel: 267-426-0930
Fax: 267-426-5476
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