EC                 Enzyme                                 

all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
SolPP synthase (ambiguous);
SPP-synthase (ambiguous);
SPP synthase (ambiguous);
solanesyl-diphosphate synthase (ambiguous);


Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)


geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units)

geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate [RN:R09250]
Reaction(KEGG) Substrate
geranyl diphosphate [CPD:C00341];
isopentenyl diphosphate [CPD:C00129]
diphosphate [CPD:C00013];
all-trans-nonaprenyl diphosphate [CPD:C04145]

(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9 [1]. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation [3].


EC created 1972 as EC, part transferred 2010 to EC

ec00900   Terpenoid backbone biosynthesis
ec01110   Biosynthesis of secondary metabolites
K05356   all-trans-nonaprenyl-diphosphate synthase
Genes  » show all
Reference   Authors

Sagami H, Ogura K, Seto S


Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus.

  Journal Reference   Authors

Fujii H, Sagami H, Koyama T, Ogura K, Seto S, Baba T, Allen CM.


Variable product specificity of solanesyl pyrophosphate synthetase.

  Journal Reference   Authors

Ohara K, Sasaki K, Yazaki K


Two solanesyl diphosphate synthases with different subcellular localizations and  their respective physiological roles in Oryza sativa.

  Journal   Sequence Reference   Authors

Ohnuma S, Koyama T, Ogura K


Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase.


J Biol Chem 266:23706-13 (1991)

Reference   Authors

Gotoh T, Koyama T, Ogura K


Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase.

  Journal Reference   Authors

Teclebrhan H, Olsson J, Swiezewska E, Dallner G


Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes.


J Biol Chem 268:23081-6 (1993)

Other DBs
ExplorEnz – The Enzyme Database:
ExPASy – ENZYME nomenclature database:

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