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KEGG ENZYME: 1.4.1.4

 October 16, 2021

Entry
EC 1.4.1.4                  Enzyme                                 
Name

glutamate dehydrogenase (NADP+);
glutamic dehydrogenase;
dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate));
glutamic acid dehydrogenase;
L-glutamate dehydrogenase;
L-glutamic acid dehydrogenase;
NAD(P)+-glutamate dehydrogenase;
NAD(P)H-dependent glutamate dehydrogenase;
glutamate dehydrogenase (NADP+)

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-glutamate:NADP+ oxidoreductase (deaminating)

Reaction(IUBMB)
L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+ [RN:R00248]
Reaction(KEGG) Substrate Product History

EC 1.4.1.4 created 1961

Pathway
ec00250   Alanine, aspartate and glutamate metabolism
ec01120   Microbial metabolism in diverse environments
Orthology
K00262   glutamate dehydrogenase (NADP+)
Genes  » show all
Reference   Authors

Coulton JW, Kapoor M.

  Title

Purification and some properties of the glutamate dehydrogenase of Salmonella typhimurium.

  Journal Reference

2

  Authors

Grisolia, S., Quijada, C.L. and Fernandez, M.

  Title

Glutamate dehydrogenase from yeast and from animal tissues.

  Journal

Biochim Biophys Acta 81:61-70 (1964)

Reference   Authors

Shiio I, Ozaki H.

  Title

Regulation of nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase from Brevibacterium flavum, a glutamate-producing bacterium.

  Journal Reference

4

  Authors

Smith, E.L., Austen, B.M., Blumenthal, K.M. and Nyc, J.F.

  Title

Glutamate dehydrogenases.

  Journal

In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 11, Academic Press, New York, 1975, p. 293-367.

Other DBs
ExplorEnz – The Enzyme Database:  1.4.1.4
IUBMB Enzyme Nomenclature:  1.4.1.4
ExPASy – ENZYME nomenclature database:  1.4.1.4
BRENDA, the Enzyme Database:  1.4.1.4

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