Posted in Research KEGG ENZYME: 1.1.3.39 October 17, 2021 KEGG ENZYME: 1.1.3.39 ENZYME: 1.1.3.39 Help Entry EC 1.1.3.39 Enzyme Name nucleoside oxidase (H2O2-forming) Class Oxidoreductases;Acting on the CH-OH group of donors;With oxygen as acceptorBRITE hierarchy Sysname nucleoside:oxygen 5′-oxidoreductase (H2O2-forming) Reaction(IUBMB) adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2 (overall reaction) [RN:R05695]; (1a) adenosine + O2 = 5′-dehydroadenosine + H2O2 [RN:R05696]; (1b) 5′-dehydroadenosine + O2 + H2O = 9-riburonosyladenine + H2O2 [RN:R05697] Reaction(KEGG) Substrate Product Comment A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2′-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5′-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water. History EC 1.1.3.39 created 2001 Reference Authors Koga S, Ogawa J, Cheng L, Choi Y, Yamada H, Shimizu S. Title Nucleoside Oxidase, a Hydrogen Peroxide-Forming Oxidase, from Flavobacterium meningosepticum. Journal Other DBs ExplorEnz – The Enzyme Database: 1.1.3.39 ExPASy – ENZYME nomenclature database: 1.1.3.39 DBGET integrated database retrieval system Read more here: Source link