KEGG ENZYME: 1.1.3.39


KEGG ENZYME: 1.1.3.39


KEGG     ENZYME: 1.1.3.39
Entry
EC 1.1.3.39                 Enzyme                                 
Name

nucleoside oxidase (H2O2-forming)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor

Sysname

nucleoside:oxygen 5′-oxidoreductase (H2O2-forming)

Reaction(IUBMB)
adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2 (overall reaction) [RN:R05695];
(1a) adenosine + O2 = 5′-dehydroadenosine + H2O2 [RN:R05696];
(1b) 5′-dehydroadenosine + O2 + H2O = 9-riburonosyladenine + H2O2 [RN:R05697]
Reaction(KEGG)
Substrate
Product
Comment
A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2′-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5′-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water.
History

EC 1.1.3.39 created 2001

Reference
  Authors

Koga S, Ogawa J, Cheng L, Choi Y, Yamada H, Shimizu S.

  Title

Nucleoside Oxidase, a Hydrogen Peroxide-Forming Oxidase, from Flavobacterium meningosepticum.

  Journal
Other DBs
ExplorEnz – The Enzyme Database:  1.1.3.39
ExPASy – ENZYME nomenclature database:  1.1.3.39

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