KEGG ENZYME: 2.1.4.1

Entry
EC 2.1.4.1                  Enzyme                                 
Name

glycine amidinotransferase;
arginine-glycine amidinotransferase;
arginine-glycine transamidinase;
glycine transamidinase

Class

Transferases;
Transferring one-carbon groups;
Amidinotransferases

Sysname

L-arginine:glycine amidinotransferase

Reaction(IUBMB)
L-arginine + glycine = L-ornithine + guanidinoacetate [RN:R00565]
Reaction(KEGG) Substrate Product Comment

Canavanine can act instead of arginine.

History

EC 2.1.4.1 created 1961 as EC 2.6.2.1, transferred 1965 to EC 2.1.4.1

Pathway
ec00260   Glycine, serine and threonine metabolism
ec00330   Arginine and proline metabolism
Orthology
K00613   glycine amidinotransferase
Genes  » show all
Reference

1

  Authors

Borsook, H. and Dubnoff, J.W.

  Title

The formation of glycocyamine in animal tissues.

  Journal

J Biol Chem 138:389-403 (1941)

Reference   Authors

CONCONI F, GRAZI E.

  Title

TRANSAMIDINASE OF HOG KIDNEY. I. PURIFICATION AND PROPERTIES.

  Journal

J Biol Chem 240:2461-4 (1965)

Reference   Authors

McGuire DM, Tormanen CD, Segal IS, Van Pilsum JF.

  Title

The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats. Purification and some properties of rat kidney transamidinase.

  Journal

J Biol Chem 255:1152-9 (1980)

  Sequence Reference

4

  Authors

Ratner, S.

  Title

Transamidination.

  Journal

In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 267-275.

Reference   Authors

RATNER S, ROCHOVANSKY O.

  Title

Biosynthesis of guanidinoacetic acid.  I.  Purification and properties of transamidinase.

  Journal Reference   Authors

RATNER S, ROCHOVANSKY O.

  Title

Biosynthesis of guanidinoacetic acid.  II.  Mechanism of amidine group transfer.

  Journal Reference   Authors

WALKER JB.

  Title

Biosynthesis of arginine from canavanine and ornithine in kidney.

  Journal

J Biol Chem 218:549-56 (1956)

Reference   Authors

WALKER JB.

  Title

Studies on the mechanism of action of kidney transamidinase.

  Journal

J Biol Chem 224:57-66 (1957)

Other DBs
ExplorEnz – The Enzyme Database:  2.1.4.1
IUBMB Enzyme Nomenclature:  2.1.4.1
ExPASy – ENZYME nomenclature database:  2.1.4.1
BRENDA, the Enzyme Database:  2.1.4.1

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