Posted in Research

KEGG ENZYME: 1.7.2.7

 October 18, 2021

Entry
EC 1.7.2.7                  Enzyme                                 
Name Class

Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor

Sysname

hydrazine:ferricytochrome-c oxidoreductase

Reaction(IUBMB)
hydrazine + H2O + 3 ferricytochrome c = nitric oxide + ammonium + 3 ferrocytochrome c [RN:R09799]
Reaction(KEGG) Substrate Product
nitric oxide [CPD:C00533];
ammonium;
ferrocytochrome c [CPD:C00126]
Comment
The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only two enzymes that are known to form an N-N bond (the other being EC 1.7.1.14, nitric oxide reductase [NAD(P)+, nitrous oxide-forming]). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is heterotrimeric and contains multiple c-type cytochromes.
History

EC 1.7.2.7 created 2016

Pathway
ec01120   Microbial metabolism in diverse environments
Orthology
K20932   hydrazine synthase subunit
K20933   hydrazine synthase subunit
K20934   hydrazine synthase subunit
Genes Reference   Authors

Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M

  Title

Molecular mechanism of anaerobic ammonium oxidation.

  Journal   Sequence Other DBs
ExplorEnz – The Enzyme Database:  1.7.2.7
IUBMB Enzyme Nomenclature:  1.7.2.7
ExPASy – ENZYME nomenclature database:  1.7.2.7
BRENDA, the Enzyme Database:  1.7.2.7

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