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KEGG ENZYME: 2.5.1.34

 October 21, 2021

Entry
EC 2.5.1.34                 Enzyme                                 
Name

4-dimethylallyltryptophan synthase;
dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase;
dimethylallyltryptophan synthetase;
dimethylallylpyrophosphate:tryptophan dimethylallyl transferase;
DMAT synthetase;
4-(gamma,gamma-dimethylallyl)tryptophan synthase;
tryptophan dimethylallyltransferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

dimethylallyl-diphosphate:L-tryptophan 4-dimethylallyltransferase

Reaction(IUBMB)
dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan [RN:R01657]
Reaction(KEGG)
R01657;
(other) R02943
Substrate
dimethylallyl diphosphate [CPD:C00235];
L-tryptophan [CPD:C00078]
Product
diphosphate [CPD:C00013];
4-(3-methylbut-2-enyl)-L-tryptophan [CPD:C04290]
History

EC 2.5.1.34 created 1984, modified 2010

Pathway
ec00901   Indole alkaloid biosynthesis
ec01110   Biosynthesis of secondary metabolites
Orthology
K14130   tryptophan 4-dimethylallyltransferase
Genes
MAW:  MAC_06989
MAJ:  MAA_06736
GLZ:  GLAREA_05930
AFM:  AFUA_2G18040
ACT:  ACLA_031240
AOR:  AO090005001079
AFV:  AFLA_003907
ABE:  ARB_04649
TVE:  TRV_01863
BSC:  COCSADRAFT_185949

Reference

1  [PMID:999297]
  Authors

Lee SL, Floss HG, Heinstein P.

  Title

Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58.

  Journal
Arch Biochem Biophys 177:84-94 (1976)
DOI:10.1016/0003-9861(76)90418-5
Other DBs
ExplorEnz – The Enzyme Database:  2.5.1.34
IUBMB Enzyme Nomenclature:  2.5.1.34
ExPASy – ENZYME nomenclature database:  2.5.1.34
BRENDA, the Enzyme Database:  2.5.1.34
CAS:  55127-01-0

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