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KEGG ENZYME: 1.1.99.6

 October 22, 2021

Entry
EC 1.1.99.6                 Enzyme                                 
Name

D-lactate dehydrogenase (acceptor);
D-2-hydroxy acid dehydrogenase;
D-2-hydroxy-acid dehydrogenase;
(R)-2-hydroxy-acid:acceptor 2-oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors

Sysname

(R)-lactate:acceptor 2-oxidoreductase

Reaction(IUBMB)
(R)-lactate + acceptor = pyruvate + reduced acceptor [RN:R00297]
Reaction(KEGG)
R00297
Substrate
(R)-lactate [CPD:C00256];
acceptor [CPD:C00028]
Product
pyruvate [CPD:C00022];
reduced acceptor [CPD:C00030]
Comment

The zinc flavoprotein (FAD) from the archaeon Archaeoglobus fulgidus cannot utilize NAD+, cytochrome c, methylene blue or dimethylnaphthoquinone as acceptors. In vitro it is active with artificial electron acceptors such as 2,6-dichlorophenolindophenol, but the physiological acceptor is not yet known.

History

EC 1.1.99.6 created 1965, modified 2013

Pathway
ec00620   Pyruvate metabolism
ec01100   Metabolic pathways
Orthology
K21836   D-lactate dehydrogenase (acceptor)
Genes
AFU:  AF_0394

Reference

1  [PMID:10601217]
  Authors

Reed DW, Hartzell PL

  Title

The Archaeoglobus fulgidus D-lactate dehydrogenase is a Zn(2+) flavoprotein.

  Journal
J Bacteriol 181:7580-7 (1999)
DOI:10.1128/JB.181.24.7580-7587.1999
  Sequence
[afu:AF_0394]
Other DBs
ExplorEnz – The Enzyme Database:  1.1.99.6
IUBMB Enzyme Nomenclature:  1.1.99.6
ExPASy – ENZYME nomenclature database:  1.1.99.6
BRENDA, the Enzyme Database:  1.1.99.6
CAS:  9028-83-5

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