KEGG ENZYME: 1.2.1.51

Entry

EC 1.2.1.51                 Enzyme

Name Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

Sysname

pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)

Reaction(IUBMB) Reaction(KEGG) Substrate Product Comment

The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen.

History

EC 1.2.1.51 created 1989

Orthology

K21682

pyruvate dehydrogenase (NADP+)

Genes Taxonomy Reference   Authors

Inui H, Miyatake K, Nakano Y, Kitaoka S.

  Title

Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis.

  Journal Reference   Authors

Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S

  Title

Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis.

  Journal

J Biol Chem 262:9130-5 (1987)

  Sequence Other DBs

ExplorEnz – The Enzyme Database:

1.2.1.51

ExPASy – ENZYME nomenclature database:

1.2.1.51