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KEGG ENZYME: 1.1.1.299

 October 23, 2021

Entry
EC 1.1.1.299                Enzyme                                 
Name

malate dehydrogenase [NAD(P)+];
MdH II, NAD(P)+-dependent malate dehyrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(S)-malate:NAD(P)+ oxidoreductase

Reaction(IUBMB)
(S)-malate + NAD(P)+ = oxaloacetate + NAD(P)H + H+ [RN:R00342 R00343]
Reaction(KEGG) Substrate Product Comment
This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1].
Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).
History

EC 1.1.1.299 created 2009

Reference   Authors

Thompson H, Tersteegen A, Thauer RK, Hedderich R

  Title

Two malate dehydrogenases in Methanobacterium thermoautotrophicum.

  Journal   Sequence Other DBs
ExPASy – ENZYME nomenclature database:  1.1.1.299

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