KEGG ENZYME: 2.4.99.1

Entry
EC 2.4.99.1                 Enzyme                                 
Name

beta-galactoside alpha-(2,6)-sialyltransferase;
ST6Gal-I;
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase;
lactosylceramide alpha-2,6-N-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase;
beta-galactoside alpha-2,6-sialyltransferase

Class

Transferases;
Glycosyltransferases;
Transferring other glycosyl groups

Sysname

CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)

Reaction(IUBMB)
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R [RN:R04532 R06188]
Reaction(KEGG) Substrate
CMP-N-acetyl-beta-neuraminate [CPD:C00128];
beta-D-galactosyl-R [CPD:C02900]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Comment

The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.

History

EC 2.4.99.1 created 1972, modified 1976, modified 1986, modified 2016 (EC 2.4.99.11 created 1992, incorporated 2016), modified 2017

Pathway
ec00514   Other types of O-glycan biosynthesis
Orthology
K00778   beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
K00779   beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
K12248   beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 0160)
Genes  » show all
Reference   Authors

Spiro MJ, Spiro RG.

  Title

Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase.

  Journal

J Biol Chem 243:6520-8 (1968)

Reference   Authors

Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH.

  Title

Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin.

  Journal

J Biol Chem 245:759-66 (1970)

Reference   Authors

Bartholomew BA, Jourdian GW, Roseman S.

  Title

The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum.

  Journal

J Biol Chem 248:5751-62 (1973)

Reference   Authors

Paulson JC, Beranek WE, Hill RL.

  Title

Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose.

  Journal

J Biol Chem 252:2356-62 (1977)

Reference   Authors

Schachter H, Narasimhan S, Gleeson P, Vella G.

  Title

Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.

  Journal Reference   Authors

Albarracin I, Lassaga FE, Caputto R.

  Title

Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide alpha 2,6-N-acetylneuraminyltransferase (EC 2.4.99.-).

  Journal Other DBs
ExplorEnz – The Enzyme Database:  2.4.99.1
ExPASy – ENZYME nomenclature database:  2.4.99.1

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