KEGG ENZYME: 2.5.1.101

Entry
EC 2.5.1.101                Enzyme                                 
Name

N,N’-diacetyllegionaminate synthase;
neuB (gene name);
legI (gene name)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase

Reaction(IUBMB)
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O = N,N’-diacetyllegionaminate + phosphate [RN:R10304]
Reaction(KEGG) Substrate
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose [CPD:C20424];
phosphoenolpyruvate [CPD:C00074];
H2O [CPD:C00001]
Product
N,N’-diacetyllegionaminate [CPD:C20418];
phosphate [CPD:C00009]
Comment

Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.

History

EC 2.5.1.101 created 2012

Pathway
ec00520   Amino sugar and nucleotide sugar metabolism
Orthology
K18430   N,N’-diacetyllegionaminate synthase
Genes  » show all
Reference   Authors

Glaze PA, Watson DC, Young NM, Tanner ME

  Title

Biosynthesis of CMP-N,N’-diacetyllegionaminic acid from UDP-N,N’-diacetylbacillosamine in Legionella pneumophila.

  Journal   Sequence Reference   Authors

Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM

  Title

The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.

  Journal   Sequence Other DBs
ExPASy – ENZYME nomenclature database:  2.5.1.101

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