The Department of Bioinformatics-BiGCaT is part of NUTRIM School of Nutrition and Translational Research in Metabolism at the Faculty of Health, Medicine and Life Sciences. It was founded in 2001 by Prof. dr. Chris Evelo aiming at employing bioinformatics approaches in systems biology to integrate experimental data and data with current knowledge. Integrative Systems Biology is being developed and applied in various research fields. The department has four core research areas; 1) metabolic diseases, 2) micronutrients, 3) toxicity and risk assessment and 4) rare diseases. Within these areas, different types of data, like transcriptomics, proteomics, metabolomics and (epi)genomics data, are integrated and combined with existing knowledge.
Chris Evelo’s BiGCaT group is involved in (inter)national initiatives to collect, share and integrate biological data. Moreover, in order to perform data analysis in a state-of-the-art manner, novel methods and tools are being developed. These include i) high-throughput data analysis pipelines, ii) semantic Web tools using RDF, ontologies and SPARQL, iii) cheminformatics software, iv) structuring and collecting biological processes in WikiPathways, v) pathway analysis in PathVisio and vi) network analysis in Cytoscape.
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