Postdoctoral Research Associate in Applied Bioinformatics at University of York

Department
A 2-year, fixed-term postdoctoral research associate position is available to work in the group of Dr Andrew Mason within the Jack Birch Unit for Molecular Carcinogenesis, part of the Department of Biology and York Biomedical Research Institute at The University of York. We are seeking a bioinformatics-focused researcher with a strong biological background, keen to work on diverse omics projects covering tissue organisation, regenerative medicine, and cancer characterisation.

The successful candidate’s primary project will form part of an international consortium recently funded by the Wellcome Leap Human Organs, Physiology and Engineering (HOPE) programme. This exciting body of work seeks to utilise the Jack Birch Unit’s expertise in ureteric biology to increase progress in the development of therapeutically-tractable kidney organoids derived from human pluripotent stem cells. Your role will be to perform single-cell characterisation of primary ureteric tissue derived from full-width histologically-normal ureter, moving beyond our existing scRNAseq characterisations focused on ureteric and bladder urothelium alone. You will use utilise both standard single cell suspensions and develop the unit’s capability to perform spatial transcriptomics, working closely with wet lab colleagues and developing the bioinformatic workflow. Following this augmented characterisation, you will compare these data to those derived from reprogrammed human cells, and from the engineered organoids.

Role
The postdoctoral research associate will lead the transcriptomic characterisation of human ureteric tissue, informing how the incorporation of a ureter to a kidney organoid affects function and form. You will refine existing single-cell transcriptomic bioinformatic approaches and expertise and, derive an up-to-date workflow for the analysis of 10x Visium spatial transcriptomics data. You will support all bioinformatic analyses across the consortium. Beyond this core project, you will work more broadly on bioinformatics projects within the scope of the Mason lab and broader Jack Birch Unit.

Skills, Experience & Qualification needed

  • Undergraduate degree in Biological Sciences and/or Bioinformatics with a 2.1 or above, or equivalent experience.
  • PhD in Biological Sciences and/or Bioinformatics.
  • Relevant theoretical knowledge in biological sciences, including good statistical practice.
  • Relevant knowledge in RNA sequencing and transcriptomic profiling, with experience in the analysis and interpretation of such data, as well as the data management requirements of a large cohort.
  • Advanced IT skills for a range of applications, from Google Apps and Microsoft Office, to specialist software, particularly for high-level programming languages such as Python or R.
  • Ability to plan and perform complex tasks with keen attention to detail, seeking advice where necessary, and maintaining accurate, thorough records.
  • Highly developed science communication skills, from a proven ability to publish robust research, to experience delivering presentations, and disseminating research to diverse audiences.
  • Ability to direct lone working as well as being a dependable group member and support to technical staff and students.

Interview date: 10 December 2021.

For informal enquiries: Please contact Dr Andrew Mason (andrew.mason@york.ac.uk) directly with any questions or to arrange an informal discussion, or, alternatively, biol-dmthub@york.ac.uk with any other questions.

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