Posted in Research

KEGG ENZYME: 2.4.1.366

 October 29, 2021

Entry
EC 2.4.1.366                Enzyme                                 
Name

ginsenoside F1 6-O-glucosyltransferase;
UGTPg101 (gene name)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucose:ginsenoside F1 6-O-glucosyltransferase

Reaction(IUBMB)
UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1 [RN:R12387]
Reaction(KEGG) Substrate
UDP-alpha-D-glucose [CPD:C00029];
ginsenoside F1 [CPD:C20780]
Product Comment
The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of ginsenoside F1. The enzyme also glucosylates the C-20 position of protopanaxatriol, which forms ginsenoside F1 (cf. EC 2.4.1.363, ginsenoside 20-O-glucosyltransferase). However, unlike EC 2.4.1.367, ginsenoside 6-O-glucosyltransferase, it is not able to glucosylate the C-6 position of protopanaxatriol when position C-20 is not glucosylated.
History

EC 2.4.1.366 created 2019

Orthology
K23523   ginsenoside F1 6-O-glucosyltransferase
Reference   Authors

Wei W, Wang P, Wei Y, Liu Q, Yang C, Zhao G, Yue J, Yan X, Zhou Z

  Title

Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts.

  Journal   Sequence Other DBs
ExPASy – ENZYME nomenclature database:  2.4.1.366

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