Bioinformatician – Hinxton | Mendeley Careers

We are looking for a structural bioinformatician who is interested in developing methods for protein structure analysis to identify biologically relevant conformational states and link these to macromolecular function. The post holder will join the Velankar team at EMBL-EBI on a 3-year collaborative project between Protein Data Bank in Europe (PDBe) and CCP4. They will implement new data analysis methods, improve biological data processing pipelines, perform data analysis, and contribute to developing user-facing web pages. This is the role for you if you are someone who is creative, curious, and ambitious with a drive to tackle impactful biological data analysis problems.

The Velankar team maintains macromolecular structure databases that form essential resources for biologists and other life-scientists worldwide, including the Protein Data Bank as a founding partner of the Worldwide Protein Data Bank organisation (wwPDB; wwpdb.org), PDBe Knowledge Base that integrates structural and functional annotations and the AlphaFold Protein Structure Database in collaboration with DeepMind. The PDBe team consists of an international and inter-disciplinary team (data curators, bioinformaticians, scientific software developers and IT specialists).

Your role

You will be in a scientific, technical role. You will work together with developers from PDBe and CCP4 to enhance the structure superposition tool GESAMT.

In this role, you will:

  • help define data standards and influence the algorithm development for the superposition of ligand binding sites, protein chains, and macromolecular assemblies;
  • build upon and maintain one of our internal data pipelines, generating superposed structures and clusters for the complete PDB archive;
  • have an experimental, innovation-driven mindset and investigate the biological relevance of distinct conformational groups, designing methods for annotating these clusters;
  • be interested in designing and developing user-facing web pages to display superposed structures to provide researchers with a larger biological context of protein structures in the PDB.

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