BioCyc ID: RXN-11667
EC Number:
4.2.1.150
Enzymes and Genes:
3-hydroxyacyl-CoA dehydrogenase FadJ:
fadJ
multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Δ3–cis– Δ2–trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase:
fadB
In Pathway:
oleate β-oxidation
Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC entry.
The reaction direction shown is in accordance with the Enzyme Commission rules (the physiological direction of the reaction, if known, is indicated by the arrow direction).
Mass balance status: Balanced.
Generic reaction:
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA ← a (2E)-2-enoyl-CoA + H2O (4.2.1.17)
Enzyme Commission Primary Name:
short-chain-enoyl-CoA hydratase
Enzyme Commission Synonyms:
3-hydroxybutyryl-CoA dehydratase,
crotonase,
crt (gene name)
Standard Gibbs Free Energy (ΔrG‘°):
2.1629639 kcal/mol
Enzyme Commission Summary:
The enzyme from the bacterium
Clostridium acetobutylicum is part of the central fermentation pathway and plays a key role in the production of both acids and solvents. It is specific for short, C4-C6, chain length substrates and exhibits an extremely high turnover number for
crotonyl-CoA. cf.
EC 4.2.1.17, enoyl-CoA hydratase and
EC 4.2.1.74, long-chain-enoyl-CoA hydratase.
Citations:
[Waterson72,
Waterson81,
Boynton96a]
Relationship Links:
BRENDA:EC:4.2.1.150,
ENZYME:EC:4.2.1.150,
IUBMB-ExplorEnz:EC:4.2.1.150
Credits:
Created in MetaCyc 13-Sep-2010 by
Caspi R,
SRI International
Imported
from MetaCyc 14-Mar-2019 by
Caspi R,
SRI International
References
Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 45:D543-550 2017
Page generated by Pathway Tools version 25.0 (software by SRI International) on Thu Nov 25, 2021, BIOCYC14.
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